ArticleLocal and regional anesthesia2012
Articaine: a review of its use for local and regional anesthesia.
Article in Local and regional anesthesia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04166890 (Comparison of the Efficacy and Safety of Two Homologous Active Principles for Local Dental Anesthesia), which is not on this map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of the Efficacy and Safety of Two Homologous Active Principles for Local Dental Anesthesia: Non-inferiority Trial
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Efficacy comparison of articaine versus lidocaine in dental anesthesia: a meta-analysis of randomized controlled trials.BMC anesthesiology · 2026Pooled it
- Articaine buccal infiltration for mandibular first molars with symptomatic irreversible pulpitis: is it as effective as inferior alveolar nerve block with lidocaine? a systematic review and meta-analysis.Clinical oral investigations · 2025Pooled it
- Can buccal infiltration of articaine replace traditional inferior alveolar nerve block for the treatment of mandibular molars in pediatric patients?: A systematic review and meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2021Pooled it
- Articaine provides a faster onset and longer duration of analgesia at lower supplemental injections compared to mepivacaine in third molar extractions.Oral and maxillofacial surgery · 2025Trial
- Anesthetic Efficacy of Buccal Infiltration Articaine versus Lidocaine for Extraction of Primary Molar Teeth.Anesthesia progress · 2019Trial
- Comparison of the effect of the lidocaine, tetracaine, and articaine application into nasal packs on pain and hemorrhage after septoplasty.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018Trial
- Analgesia and side effects of the addition of 10 or 20 µg fentanyl to articaine in spinal anesthesia for knee arthroscopy: a randomized and observer-blinded study.Journal of anesthesia · 2017Trial
- Comparison of anesthetic efficacy of 2 and 4 % articaine in inferior alveolar nerve block for tooth extraction-a double-blinded randomized clinical trial.Clinical oral investigations · 2017Trial
- Trial
- Effect of laser-assisted articaine local anesthesia in single visit root canal treatment for mandibular molar with symptomatic irreversible pulpitis - A randomized clinical trial.Journal of conservative dentistry and endodontics · 2026Article
- Sorbent Strip Microextraction as a Practical Tool for Drug Screening: Application to Opioids and Local Anesthetics in Human Urine.Molecules (Basel, Switzerland) · 2026Article
- Lumbosacral epidural administration of 4% articaine with epinephrine in dromedary camels (Frontiers in veterinary science · 2026Article
- Comparative Evaluation of Pain Control Using 4% Articaine Buccal Infiltration and 2% Lignocaine Inferior Alveolar Nerve Block for Pulpectomy in Primary Mandibular Second Molars in the Children of Age-group 6-10 Years: A Split-mouth Randomized Controlled Clinical Trial.International journal of clinical pediatric dentistry · 2025Article
- Article
- Intrapulpal anesthesia in endodontics: an updated literature review.Journal of dental anesthesia and pain medicine · 2024Review
- Article
- Pain Mitigation Strategies for Disbudding in Goat Kids.Animals : an open access journal from MDPI · 2024Review
- Application of articaine in endoscopic endonasal dacryocystorhinostomy: a retrospective study.Frontiers in medicine · 2024Article
- Review
- Effect of local anesthetics on renal function: An animal study in Iran.Dental research journal · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Articaine is an intermediate-potency, short-acting amide local anesthetic with a fast metabolism due to an ester group in its structure. It is effective with local infiltration or peripheral nerve block in dentistry, when administered as a spinal, epidural, ocular, or regional nerve block, or when injected intravenously for regional anesthesia. In comparative trials, its clinical effects were not generally significantly different from those of other short-acting local anesthetics like lidocaine, prilocaine, and chloroprocaine, and there is no conclusive evidence demonstrating above-average neurotoxicity. Articaine proved to be suitable and safe for procedures requiring a short duration of action in which a fast onset of anesthesia is desired, eg, dental procedures and ambulatory spinal anesthesia, in normal and in special populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.