ArticleJournal of virology2012
Susceptibility of young sheep to oral infection with bovine spongiform encephalopathy decreases significantly after weaning.
Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Oral Transmission of Classical Bovine Spongiform Encephalopathy in ARR/ARR Sheep.Emerging infectious diseases · 2025Article
- No evidence of subclinical infection in sheep surviving oral challenge with prions.The Journal of general virology · 2025Article
- No evidence of uptake or propagation of reindeer CWD prions in environmentally exposed sheep.Acta veterinaria Scandinavica · 2022Article
- Prion Infectivity and PrPInternational journal of molecular sciences · 2021Article
- BSE can propagate in sheep co-infected or pre-infected with scrapie.Scientific reports · 2021Article
- Preclinical transmission of prions by blood transfusion is influenced by donor genotype and route of infection.PLoS pathogens · 2021Article
- Bovine Spongiform Encephalopathy - A Review from the Perspective of Food Safety.Food safety (Tokyo, Japan) · 2019Review
- Effect of co-infection with a small intestine-restricted helminth pathogen on oral prion disease pathogenesis in mice.Scientific reports · 2019Article
- Sheep Are Susceptible to the Bovine Adapted Transmissible Mink Encephalopathy Agent by Intracranial Inoculation and Have Evidence of Infectivity in Lymphoid Tissues.Frontiers in veterinary science · 2019Article
- Clinical, pathological, and molecular features of classical and L-type atypical-BSE in goats.PloS one · 2018Article
- Prion Strains and Transmission Barrier Phenomena.Pathogens (Basel, Switzerland) · 2018Review
- Detection of PrPVeterinary research · 2017Article
- How do PrPPathogens (Basel, Switzerland) · 2017Review
- Protecting effect of PrP codons M142 and K222 in goats orally challenged with bovine spongiform encephalopathy prions.Veterinary research · 2017Article
- Genetic resistance to transmissible spongiform encephalopathies (TSE) in goats.EFSA journal. European Food Safety Authority · 2017Article
- Pathways of Prion Spread during Early Chronic Wasting Disease in Deer.Journal of virology · 2017Article
- Transmission of sheep-bovine spongiform encephalopathy to pigs.Veterinary research · 2016Article
- Article
- Dynamics of the natural transmission of bovine spongiform encephalopathy within an intensively managed sheep flock.Veterinary research · 2015Review
- Archival search for historical atypical scrapie in sheep reveals evidence for mixed infections.The Journal of general virology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Bovine spongiform encephalopathy (BSE) is a transmissible spongiform encephalopathy (TSE) (or prion disease) that is readily transmissible to sheep by experimental infection and has the shortest incubation period in animals with the ARQ/ARQ PRNP genotype (at codons 136, 154, and 171). Because it is possible that sheep in the United Kingdom could have been infected with BSE by being fed contaminated meat and bone meal supplements at the same time as cattle, there is considerable interest in the responses of sheep to BSE inoculation. Epidemiological evidence suggests that very young individuals are more susceptible to TSE infection; however, this has never been properly tested in sheep. In the present study, low doses of BSE were fed to lambs of a range of ages (~24 h, 2 to 3 weeks, 3 months, and 6 months) and adult sheep. The incidence of clinical BSE disease after inoculation was high in unweaned lambs (~24 h and 2 to 3 weeks old) but much lower in older weaned animals The incubation period was also found to be influenced by the genotype at codon 141 of the PRNP gene, as lambs that were LF heterozygotes had a longer mean incubation period than those that were homozygotes of either type. The results suggest that sheep in the United Kingdom would have been at high risk of BSE infection only if neonatal animals had inadvertently ingested contaminated supplementary foodstuffs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.