ArticleJournal of experimental botany2012
Haem oxygenase-1 is involved in salicylic acid-induced alleviation of oxidative stress due to cadmium stress in Medicago sativa.
Article in Journal of experimental botany, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 86 citations in OpenAlex.
- Jasmonic Acid and Salicylic Acid in Regulating Plant Cadmium Accumulation and Tolerance: Mechanisms and Crosstalk.Plants (Basel, Switzerland) · 2026Review
- Identification ofInternational journal of molecular sciences · 2025Article
- The photo-protective role of vitamin D in the microalgaiScience · 2024Article
- Metabolic Adaptations in Rapeseed: Hemin-Induced Resilience to NaCl Stress by Enhancing Growth, Photosynthesis, and Cellular Defense Ability.Metabolites · 2024Article
- Article
- Comprehensive transcriptome analysis unravels the crucial genes during adventitious root development induced by carbon monoxide in Cucumis sativus L.Molecular biology reports · 2022Article
- Heme Oxygenase/Carbon Monoxide Participates in the Regulation ofInternational journal of molecular sciences · 2022Article
- Alleviation of cadmium phytotoxicity through melatonin modulated physiological functions, antioxidants, and metabolites in tomato (Solanum lycopersicum L.).Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022Article
- Salicylic Acid Enhances Heat Stress Resistance ofAntioxidants (Basel, Switzerland) · 2022Article
- The elemental defense effect of cadmium on Alternaria brassicicola in Brassica juncea.BMC plant biology · 2022Article
- Salicylic acid alleviates chromium (VI) toxicity by restricting its uptake, improving photosynthesis and augmenting antioxidant defense inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- Exogenous hemin improves CdScientific reports · 2021Article
- Acclimation of cadmium-induced genotoxicity and oxidative stress in mung bean seedlings by priming effect of phytohormones and proline.PloS one · 2021Article
- Genome-Wide Investigation of the Cysteine Synthase Gene Family Shows That Overexpression ofFrontiers in plant science · 2021Article
- Article
- Transcriptome analysis reveals insight into molecular hydrogen-induced cadmium tolerance in alfalfa: the prominent role of sulfur and (homo)glutathione metabolism.BMC plant biology · 2020Article
- The Role of Salicylic Acid in Plants Exposed to Heavy Metals.Molecules (Basel, Switzerland) · 2020Review
- Seed Priming Improved Antioxidant Defense System and Alleviated Ni-Induced Adversities in Rice Seedlings Under N, P, or K Deprivation.Frontiers in plant science · 2020Article
- Salicylic Acid Signals Plant Defence against Cadmium Toxicity.International journal of molecular sciences · 2019Review
- Trithorax-group protein ATX5 mediates the glucose response via impacting the HY1-ABI4 signaling module.Plant molecular biology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This work examines the involvement of haem oxygenase-1 (HO-1) in salicylic acid (SA)-induced alleviation of oxidative stress as a result of cadmium (Cd) stress in alfalfa (Medicago sativa L.) seedling roots. CdCl(2) exposure caused severe growth inhibition and Cd accumulation, which were potentiated by pre-treatment with zinc protoporphyrin (ZnPPIX), a potent HO-1 inhibitor. Pre-treatment of plants with the HO-1 inducer haemin or SA, both of which could induce MsHO1 gene expression, significantly reduced the inhibition of growth and Cd accumulation. The alleviation effects were also evidenced by a decreased content of thiobarbituric acid-reactive substances (TBARS). The antioxidant behaviour was confirmed by histochemical staining for the detection of lipid peroxidation and the loss of plasma membrane integrity. Furthermore, haemin and SA pre-treatment modulated the activities of ascorbate peroxidase (APX), superoxide dismutase (SOD), and guaiacol peroxidase (POD), or their corresponding transcripts. Significant enhancement of the ratios of reduced/oxidized homoglutathione (hGSH), ascorbic acid (ASA)/dehydroascorbate (DHA), and NAD(P)H/NAD(P)(+), and expression of their metabolism genes was observed, consistent with a decreased reactive oxygen species (ROS) distribution in the root tips. These effects are specific for HO-1, since ZnPPIX blocked the above actions, and the aggravated effects triggered by SA plus ZnPPIX were differentially reversed when carbon monoxide (CO) or bilirubin (BR), two catalytic by-products of HO-1, was added. Together, the results suggest that HO-1 is involved in the SA-induced alleviation of Cd-triggered oxidative stress by re-establishing redox homeostasis.
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