ArticleJournal of the Royal Society, Interface2012
Heat-shock-induced cellular responses to temperature elevations occurring during orthopaedic cutting.
Article in Journal of the Royal Society, Interface, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 79 citations in OpenAlex.
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- The effects of multiple drilling of a bone with the same drill bit: thermal and force analysis.Heliyon · 2022Article
- Bone cement as a local chemotherapeutic drug delivery carrier in orthopedic oncology: A review.Journal of bone oncology · 2021Review
- Comparison of Surgical Smoke Generated During Electrosurgery with Aerosolized Particulates from Ultrasonic and High-Speed Cutting.Annals of biomedical engineering · 2021Article
- Surgical Drill Bit Design and Thermomechanical Damage in Bone Drilling: A Review.Annals of biomedical engineering · 2021Review
- Piezoelectric Implant Site Preparation: Influence of Handpiece Movements on Temperature Elevation.Materials (Basel, Switzerland) · 2020Article
- VNUT/SLC17A9, a vesicular nucleotide transporter, regulates osteoblast differentiation.FEBS open bio · 2020Article
- Apoptotic Osteocytes Induce RANKL Production in Bystanders via Purinergic Signaling and Activation of Pannexin Channels.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020Article
- Rapid Characterization of Biomolecules' Thermal Stability in a Segmented Flow-Through Optofluidic Microsystem.Scientific reports · 2020Article
- Bioinspired extracellular vesicles embedded with black phosphorus for molecular recognition-guided biomineralization.Nature communications · 2019Article
- A Novel Osteotomy Preparation Technique to Preserve Implant Site Viability and Enhance Osteogenesis.Journal of clinical medicine · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe heat-shock to bone cells caused during orthopaedic procedures can result in thermal damage, leading to cell death and initiating bone resorption. By contrast, mild heat-shock has been proposed to induce bone regeneration. In this study, bone cells are exposed to heat-shock for short durations occurring during surgical cutting. Cellular viability, necrosis and apoptosis are investigated immediately after heat-shock and following recovery of 12, 24 h and 4 days, in osteocyte-like MLO-Y4 and osteoblast-like MC3T3-E1 cells, using flow cytometry. The regeneration capacity of heat-shocked Balb/c mesenchymal stem cells (MSCs) and MC3T3-E1s has been investigated following 7 and 14 day's recovery, by quantifying proliferation, differentiation and mineralization. An immediate necrotic response to heat-shock was shown in cells exposed to elevated temperatures (45°C, 47°C and most severe at 60°C). A longer-term apoptotic response is induced in MLO-Y4s and, to a lesser extent, in MC3T3-E1s. Heat-shock-induced differentiation and mineralization by MSCs. These findings indicate that heat-shock is more likely to induce apoptosis in osteocytes than osteoblasts, which might reflect their role as sensors detecting and communicating damage within bone. Furthermore, it is shown for the first time that mild heat-shock (less than equal to 47°C) for durations occurring during surgical cutting can positively enhance osseointegration by osteoprogenitors.
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