ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2013
Does a childhood fracture predict low bone mass in young adulthood? A 27-year prospective controlled study.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Association of serum 25(OH)Vit-D levels with risk of pediatric fractures: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Pooled it
- Is repeated childhood fracture related to areal bone density or body composition in middle age?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Article
- Decreased Levels of Circulating Carboxylated Osteocalcin in Children with Low Energy Fractures: A Pilot Study.Nutrients · 2018Article
- Do bone mineral content and density determine fracture in children? A possible threshold for physical activity.Pediatric research · 2017Article
- Epidemiology and time trends of distal forearm fractures in adults - a study of 11.2 million person-years in Sweden.BMC musculoskeletal disorders · 2017Article
- Increasing wrist fracture rates in children may have major implications for future adult fracture burden.Acta orthopaedica · 2016Article
- Skeletal changes through the lifespan--from growth to senescence.Nature reviews. Endocrinology · 2015Review
- Diminished bone strength is observed in adult women and men who sustained a mild trauma distal forearm fracture during childhood.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- Femur shaft fracture at a young age and the risk of subsequent severe injuries during childhood: a cohort study.BMC pediatrics · 2014Article
- Fracture patterns and bone mass in South African adolescent-mother pairs: the Birth to Twenty cohort.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- A distal forearm fracture in childhood is associated with an increased risk for future fragility fractures in adult men, but not women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013Article
- Causes, mechanisms and management of paediatric osteoporosis.Nature reviews. Rheumatology · 2013Review
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6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A fracture in childhood is associated with low bone mineral density (BMD), but it is debated whether a fracture at growth also predicts low BMD in young adulthood. The purpose of this work was to gender-specifically evaluate whether children with a fracture are at increased risk of low BMD in young adulthood. Distal forearm BMD (g/cm2) was measured with single-photon absorptiometry (SPA) in 47 boys and 26 girls (mean age 10 years, range 3-16 years) with an index fracture and in 41 boys and 43 girls (mean age 10 years, range 4-16 years) with no fracture. BMD was re-measured mean 27 years later with the same SPA apparatus and with dual-energy absorptiometry (DXA), quantitative ultrasound (QUS), and peripheral computed tomography (pQCT). Individual Z-scores were calculated using the control cohort as reference population. Data are presented as means with 95% confidence intervals (95% CI) within brackets and correlation with Pearson's correlation coefficient. Boys with an index fracture had at fracture event a distal forearm BMD Z-score of -0.4 (95% CI, -0.7 to -0.1) and at follow-up -0.4 (95% CI, -0.7 to -0.1). Corresponding values in girls were -0.2 (95% CI, -0.5 to 0.1) and -0.3 (95% CI, -0.7 to 0.1). The deficit in absolute bone mass was driven by men with index fractures in childhood due to low energy rather than moderate or high energy. There were no changes in BMD Z-score during the follow-up period. The BMD deficit at follow-up was in boys with an index fracture verified with all advocated techniques. A childhood fracture in men was associated with low BMD and smaller bone size in young adulthood whereas the deficit in women did not reach statistical significance.
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