ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Two Drosophila DEG/ENaC channel subunits have distinct functions in gustatory neurons that activate male courtship.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 40 citations in OpenAlex.
- Courtship song differs between African and European populations of Drosophila melanogaster and involves a strong effect locus.G3 (Bethesda, Md.) · 2025Article
- The diverse functions of the DEG/ENaC family: linking genetic and physiological insights.The Journal of physiology · 2023Article
- Understanding the impact of sociosexual interactions on sleep usingFrontiers in physiology · 2023Article
- A Sexually Dimorphic Olfactory Neuron Mediates Fixed Action Transition during Courtship Ritual inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Review
- DEG/ENaC Ion Channels in the Function of the Nervous System: From Worm to Man.Advances in experimental medicine and biology · 2021Article
- Molecular mechanisms of olfactory detection in insects: beyond receptors.Open biology · 2020Article
- Neuronal Compartmentalization: A Means to Integrate Sensory Input at the Earliest Stage of Information Processing?BioEssays : news and reviews in molecular, cellular and developmental biology · 2020Article
- Contact-Chemosensory Evolution Underlying Reproductive Isolation inFrontiers in behavioral neuroscience · 2020Review
- Article
- UsingFrontiers in cellular neuroscience · 2018Review
- Article
- TheThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
- Article
- Pheromone processing in Drosophila.Current opinion in neurobiology · 2015Review
- Gr33a modulates Drosophila male courtship preference.Scientific reports · 2015Article
- Drosophila Bitter Taste(s).Frontiers in integrative neuroscience · 2015Review
- Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Trimeric sodium channels of the DEG/ENaC family have important roles in neurons, but the specific functions of different subunits present in heteromeric channels are poorly understood. We previously reported that the Drosophila DEG/ENaC subunit Ppk25 is essential in a small subset of gustatory neurons for activation of male courtship behavior, likely through detection of female pheromones. Here we show that, like mutations in ppk25, mutations in another Drosophila DEG/ENaC subunit gene, nope, specifically impair male courtship of females. nope regulatory sequences drive reporter gene expression in gustatory neurons of the labellum wings, and legs, including all gustatory neurons in which ppk25 function is required for male courtship of females. In addition, gustatory-specific knockdown of nope impairs male courtship. Further, the impaired courtship response of nope mutant males to females is rescued by targeted expression of nope in the subset of gustatory neurons in which ppk25 functions. However, nope and ppk25 have nonredundant functions, as targeted expression of ppk25 does not compensate for the lack of nope and vice versa. Moreover, Nope and Ppk25 form specific complexes when coexpressed in cultured cells. Together, these data indicate that the Nope and Ppk25 polypeptides have specific, nonredundant functions in a subset of gustatory neurons required for activation of male courtship in response to females, and suggest the hypothesis that Nope and Ppk25 function as subunits of a heteromeric DEG/ENaC channel required for gustatory detection of female pheromones.
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