ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Presynaptic but not postsynaptic GABA signaling at unitary mossy fiber synapses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 31 citations in OpenAlex.
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- Cognitive enrichment improves spatial memory and alters hippocampal synaptic connectivity in a mouse model for early-life stress.Frontiers in cellular neuroscience · 2025Article
- Multifaceted circuit functions of adult-born neurons.F1000Research · 2019Review
- Biphasic modulation of parallel fibre synaptic transmission by co-activation of presynaptic GABAA and GABAB receptors in mice.The Journal of physiology · 2016Article
- Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons.Hippocampus · 2016Article
- Viral and transgenic reporters and genetic analysis of adult neurogenesis.Cold Spring Harbor perspectives in biology · 2015Review
- Dual-transmitter neurons: functional implications of co-release and co-transmission.Current opinion in neurobiology · 2014Review
- Mood regulation. GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment.Science (New York, N.Y.) · 2014Article
- The emerging role of GABAB receptors as regulators of network dynamics: fast actions from a 'slow' receptor?Current opinion in neurobiology · 2014Review
- Functions and dysfunctions of adult hippocampal neurogenesis.Annual review of neuroscience · 2014Review
- Electrophysiological characterization of granule cells in the dentate gyrus immediately after birth.Frontiers in cellular neuroscience · 2014Article
- Mixed neurotransmission in the hippocampal mossy fibers.Frontiers in cellular neuroscience · 2013Review
- Is GABA co-released with glutamate from hippocampal mossy fiber terminals?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Toward a self-wired active reconstruction of the hippocampal trisynaptic loop: DG-CA3.Frontiers in neural circuits · 2013Article
- Molecular and functional characterization of GAD67-expressing, newborn granule cells in mouse dentate gyrus.Frontiers in neural circuits · 2013Article
- Dynamic functions of GABA signaling during granule cell maturation.Frontiers in neural circuits · 2012Article
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4 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Dentate gyrus granule cells have been suggested to corelease GABA and glutamate both in juvenile animals and under pathological conditions in adults. Although mossy fiber terminals (MFTs) are known to express glutamic acid decarboxylase (GAD) in early postnatal development, the functional role of GABA synthesis in MFTs remains controversial, and direct evidence for synaptic GABA release from MFTs is missing. Here, using GAD67-GFP transgenic mice, we show that GAD67 is expressed only in a population of immature granule cells in juvenile animals. We demonstrate that GABA can be released from these cells and modulate mossy fiber excitability through activation of GABAB autoreceptors. However, unitary postsynaptic currents generated by individual, GAD67-expressing granule cells are purely glutamatergic in all postsynaptic cell types tested. Thus GAD67 expression does not endow dentate gyrus granule cells with a full GABAergic phenotype and GABA primarily instructs the pre- rather than the postsynaptic element.
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