ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Clinically relevant hormone treatments fail to induce spinogenesis in prefrontal cortex of aged female rhesus monkeys.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Distinct cognitive effects of estrogen and progesterone in menopausal women.Psychoneuroendocrinology · 2015Trial
- Hormonal milieu influences whole-brain structural dynamics across the menstrual cycle using dense sampling in multiple individuals.Nature neuroscience · 2025Article
- Spectral dynamic causal modelling in healthy women reveals brain connectivity changes along the menstrual cycle.Communications biology · 2021Article
- The scientific body of knowledge - Whose body does it serve? A spotlight on oral contraceptives and women's health factors in neuroimaging.Frontiers in neuroendocrinology · 2021Review
- Selective Loss of Thin Spines in Area 7a of the Primate Intraparietal Sulcus Predicts Age-Related Working Memory Impairment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Timing of cyclic estradiol treatment differentially affects cognition in aged female rhesus monkeys.Behavioral neuroscience · 2018Article
- Effect of Estradiol on Neurotrophin Receptors in Basal Forebrain Cholinergic Neurons: Relevance for Alzheimer's Disease.International journal of molecular sciences · 2016Review
- Age and Long-Term Hormone Treatment Effects on the Ultrastructural Morphology of the Median Eminence of Female Rhesus Macaques.Neuroendocrinology · 2016Article
- Estrogen Effects on Cognitive and Synaptic Health Over the Lifecourse.Physiological reviews · 2015Review
- Differential effects of aging on dendritic spines in visual cortex and prefrontal cortex of the rhesus monkey.Neuroscience · 2014Article
- Alzheimer's disease: review of hormone therapy trials and implications for treatment and prevention after menopause.The Journal of steroid biochemistry and molecular biology · 2014Review
- GnRH neurons of young and aged female rhesus monkeys co-express GPER but are unaffected by long-term hormone replacement.Neuroendocrinology · 2014Article
- Ovarian adrenal interactions during the menopausal transition.Minerva ginecologica · 2013Article
- Multiple clinically relevant hormone therapy regimens fail to improve cognitive function in aged ovariectomized rhesus monkeys.Neurobiology of aging · 2013Article
- Critical window hypothesis of hormone therapy and cognition: a scientific update on clinical studies.Menopause (New York, N.Y.) · 2013Review
- Continuously delivered ovarian steroids do not alter dendritic spine density or morphology in macaque dorsolateral prefrontal cortical neurons.Neuroscience · 2013Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Preclinical animal models have provided strong evidence that estrogen (E) therapy (ET) enhances cognition and induces spinogenesis in neuronal circuits. However, clinical studies have been inconsistent, with some studies revealing adverse effects of ET, including an increased risk of dementia. In an effort to bridge this disconnect between the preclinical and clinical data, we have developed a nonhuman primate (NHP) model of ET combined with high-resolution dendritic spine analysis of dorsolateral prefrontal cortical (dlPFC) neurons. Previously, we reported cyclic ET in aged, ovariectomized NHPs increased spine density on dlPFC neurons. Here, we report that monkeys treated with cyclic E treatment paired with cyclic progesterone (P), continuous E combined with P (either cyclic or continuous), or unopposed continuous E failed to increase spines on dlPFC neurons. Given that the most prevalent form of ET prescribed to women is a combined and continuous E and P, these data bring into convergence the human neuropsychological findings and preclinical neurobiological evidence that standard hormone therapy in women is unlikely to yield the synaptic benefit presumed to underlie the cognitive enhancement reported in animal models.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.