ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
A GABAergic inhibitory neural circuit regulates visual reversal learning in Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 47 citations in OpenAlex.
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- A social learning primacy trend in mate-copying: an experiment inRoyal Society open science · 2024Article
- Octopamine in the mushroom body circuitry for learning and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Diverse memory paradigms inLearning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Rewarding Capacity of Optogenetically Activating a Giant GABAergic Central-Brain Interneuron in LarvalThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Idiosyncratic learning performance in flies.Biology letters · 2022Article
- From Photons to Behaviors: Neural Implementations of Visual Behaviors inFrontiers in neuroscience · 2022Review
- Article
- Dopaminergic mechanism underlying reward-encoding of punishment omission during reversal learning in Drosophila.Nature communications · 2021Article
- Neural Circuits Underlying Behavioral Flexibility: Insights FromFrontiers in behavioral neuroscience · 2021Review
- A neural algorithm for Drosophila linear and nonlinear decision-making.Scientific reports · 2020Article
- Localized inhibition in theeLife · 2020Article
- Cellular and circuit mechanisms of olfactory associative learning inJournal of neurogenetics · 2020Review
- Reversal learning inLearning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Cloning and Functional Characterisation of the Duplicated RDL Subunits from the Pea Aphid,International journal of molecular sciences · 2018Article
- Functional architecture of reward learning in mushroom body extrinsic neurons of larval Drosophila.Nature communications · 2018Article
- Relationship between brain plasticity, learning and foraging performance in honey bees.PloS one · 2018Article
- Experience during early adulthood shapes the learning capacities and the number of synaptic boutons in the mushroom bodies of honey bees (Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflexible cognition and behavior are prominent features of prefrontal cortex damage and several neuropsychiatric disorders. The ability to flexibly adapt cognitive processing and behavior to dynamically changing environmental contingencies has been studied using the reversal learning paradigm in mammals, but the complexity of the brain circuits precludes a detailed analysis of the underlying neural mechanism. Here we study the neural circuitry mechanism supporting flexible behavior in a genetically tractable model organism, Drosophila melanogaster. Combining quantitative behavior analysis and genetic manipulation, we found that inhibition from a single pair of giant GABAergic neurons, the anterior paired lateral (APL) neurons, onto the mushroom bodies (MBs) selectively facilitates behavioral flexibility during visual reversal learning. This effect was mediated by ionotropic GABA(A) receptors in the MB. Moreover, flies with perturbed MB output recapitulated the poor reversal performance of flies with dysfunctional APL neurons. Importantly, we observed that flies with dysfunctional APL-MB circuit performed normally in simple forms of visual learning, including initial learning, extinction, and differential conditioning. Finally, we showed that acute disruption of the APL-MB circuit is sufficient to impair visual reversal learning. Together, these data suggest that the APL-MB circuit plays an essential role in the resolution of conflicting reinforcement contingencies and reveals an inhibitory neural mechanism underlying flexible behavior in Drosophila.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.