ArticleEuropean journal of clinical pharmacology2013
Drug-induced anaphylaxis: a decade review of reporting to the Portuguese Pharmacovigilance Authority.
Article in European journal of clinical pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 91 citations in OpenAlex.
- Disparities in rate, triggers, and management in pediatric and adult cases of suspected drug-induced anaphylaxis in Canada.Immunity, inflammation and disease · 2018Trial
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- Analysis of Allergy and Hypersensitivity Reactions to COVID-19 Vaccines According to the EudraVigilance Database.Life (Basel, Switzerland) · 2024Article
- Serum MRGPRX2 as a Long-term Biomarker for Iodinated Contrast Media-Induced Anaphylaxis.Allergy, asthma & immunology research · 2024Article
- Non-IgE-Mediated Immediate Drug-Induced Hypersensitivity Reactions.The journal of allergy and clinical immunology. In practice · 2024Article
- Hypersensitivity Reactions to Taxanes: A Multicenter Study for Outcomes and Safety of Rapid Drug Desensitization.Allergy, asthma & immunology research · 2024Article
- Clinical characteristics and risk factors analysis of 505 cases of infusion reactions in a tertiary hospital.Frontiers in pharmacology · 2024Article
- A Sex- and Gender-Based Analysis of Adverse Drug Reactions: A Scoping Review of Pharmacovigilance Databases.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Biological screening of a unique drug library targeting MRGPRX2.Frontiers in immunology · 2022Article
- Omalizumab for successful chemotherapy desensitisation: What we know so far.Clinical and translational allergy · 2021Review
- To perform genotyping of dihydropyrimidine dehydrogenase (DPD) before starting treatment with 5-fluorouracil or related medicines: really feasible?International journal of colorectal disease · 2021Article
- Common causes and characteristics of adverse drug reactions in older adults: a retrospective study.BMC pharmacology & toxicology · 2020Article
- Epidemiology and drug allergy results in children investigated in allergy unit of a tertiary-care paediatric hospital setting.Italian journal of pediatrics · 2020Article
- Results of Intradermal Skin Testing with Cefazolin according to a History of Hypersensitivity to Antibiotics.Journal of Korean medical science · 2019Article
- Medical malpractice related to drug-induced anaphylaxis: An analysis of lawsuit judgments in South Korea.Medicine · 2019Article
- Antibiotic prophylaxis for the prevention of infective endocarditis for dental procedures is not associated with fatal adverse drug reactions in France.Medicina oral, patologia oral y cirugia bucal · 2019Article
- Drug-Induced Anaphylaxis in a Vietnamese Pharmacovigilance Database: Trends and Specific Signals from a Disproportionality Analysis.Drug safety · 2019Article
- Drug-induced anaphylactic reactions in children: A retrospective analysis of 159 validated spontaneous reports.Pharmacoepidemiology and drug safety · 2019Article
- Drug-Induced Anaphylaxis Documented in Electronic Health Records.The journal of allergy and clinical immunology. In practice · 2019Article
- Drug-induced anaphylaxis in China: a 10 year retrospective analysis of the Beijing Pharmacovigilance Database.International journal of clinical pharmacy · 2018Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAnaphylaxis is a potentially fatal systemic adverse drug reaction (ADR). It is an unpredictable and mostly dose-independent event that occurs suddenly following exposure to the causative drug. Our objective was to characterize a case series of anaphylactic reactions reported to the Portuguese Pharmacovigilance authority during the past decade. Patients' demographic data and implicated drugs were analyzed as well as the severity of the ADR and time trends.
methodsThis study was a retrospective analysis of episodes of anaphylaxis, defined according to the Second Symposium on the Definition and Management of Anaphylaxis Criteria, reported to the Portuguese Pharmacovigilance System between 1 January 2000 and 1 November 2010
resultsAmongst the 16,157 ADR reported to the Portuguese Pharmacovigilance System during the 10-year study period, we found 918 (6 %) cases of anaphylaxis that met the proposed criteria. The age of the patients varied from 7 days to 91 years, with 87 cases (9 %) of anaphylaxis involving patients under 18 years of age. There was an overall female predominance (67 %), but the majority of pediatric patients were male (56 %). There was a trend toward increased reporting as the decade progressed, and 31 % (284) of all anaphylaxis cases were reported during the last 2 years of the study period. Of the anaphylaxis episodes reported, 19 % led to hospitalization and 24 (3 %) had a fatal outcome. Antibiotics were responsible for most cases (17 %) followed by nonsteroidal anti-inflammatory drugs/acetaminophen (13 %), antineoplastic/cytotoxic drugs and immune-modulators. Vaccines and radiographic contrast media were also important contributors to an anaphylactic event.
conclusionsIn this series of drug-related anaphylaxis, we found that most of the reported episodes were associated with widely used drugs, such as antibiotics and analgesics. Anaphylaxis can occur at any age. The female gender was more highly represented, with the exception of pediatric patients.
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