ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2012
A high positive lymph node ratio is associated with distant recurrence after surgical resection of ampullary carcinoma.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- The clinical significance of the lymph node ratio as a recurrence indicator in ampullary cancer after curative pancreaticoduodenectomy.Langenbeck's archives of surgery · 2024Article
- Prediction of tumor recurrence and poor survival of ampullary adenocarcinoma using preoperative clinical and CT findings.European radiology · 2021Article
- Use of Nodal Staging Score in Evaluating the Accuracy of Pathologic Nodal Status in Node-Negative Ampullary Carcinoma.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Article
- Prognostic value of the lymph node metastasis in patients with ampulla of Vater cancer after surgical resection.Annals of hepato-biliary-pancreatic surgery · 2021Article
- The Prognostic Relevance of the Number and Location of Positive Lymph Nodes for Ampulla of Vater Carcinoma.World journal of surgery · 2021Article
- Development and Validation of a New Lymph Node Ratio-Based Staging System for Ampullary Carcinoma After Curative Pancreaticoduodenectomy.Frontiers in oncology · 2021Article
- Score for the Overall Survival Probability of Patients With Pancreatic Adenocarcinoma of the Body and Tail After Surgery: A Novel Nomogram-Based Risk Assessment.Frontiers in oncology · 2020Article
- Overall survival in patients over 40 years old with surgically resected pancreatic carcinoma: a SEER-based nomogram analysis.BMC cancer · 2019Article
- Prognostic importance of lymph node ratio after resection of ampullary carcinomas.Journal of gastrointestinal oncology · 2018Article
- Nomograms predict long-term survival for patients with periampullary adenocarcinoma after pancreatoduodenectomy.BMC cancer · 2018Article
- Overall survival and cancer-specific survival in patients with surgically resected pancreatic head adenocarcinoma: A competing risk nomogram analysis.Journal of Cancer · 2018Article
- Substaging Nodal Status in Ampullary Carcinomas has Significant Prognostic Value: Proposed Revised Staging Based on an Analysis of 313 Well-Characterized Cases.Annals of surgical oncology · 2015Article
- Prognostic impact of immunohistochemical expression of CK7 and CK20 in curatively resected ampulla of Vater cancer.BMC gastroenterology · 2015Article
- Prognostic Value of the Metastatic Lymph Node Ratio in Patients With Resectable Carcinoma of Ampulla of Vater.Medicine · 2015Article
- Prognostic factors of carcinoma of the ampulla of Vater after surgery.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Prognostic relevance of number and ratio of metastatic lymph nodes in resected carcinoma of the ampulla of Vater.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2013Article
- The role of local excision in invasive adenocarcinoma of the ampulla of Vater.Journal of gastrointestinal oncology · 2013Article
- PROGNOSTIC FACTORS IN PATIENTS WITH SURGICAL RESECTION OF PANCREATIC NEUROENDOCRINE TUMOURS.Acta endocrinologica (Bucharest, Romania : 2005)Article
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9 authors at 1 institution in 1 country.
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Abstract
backgroundFor ampullary carcinoma (AC), the lymph node ratio (LNR) has been associated with overall survival. However, the use of the LNR to predict distant recurrence risk remains unknown. The purpose of this study was to determine if the LNR is associated with distant recurrence risk.
methodsOne hundred forty three patients with AC who underwent pancreaticoduodenectomy between 1989 and 2011 were identified from a single-institution prospective database. Data on clinicopathologic factors and recurrence were analyzed.
resultsAt a median follow-up of 43 months (62 months for survivors), 55 patients (38 %) had developed recurrent disease, with a median time to recurrence of 13 months. Patients with a LNR ≥ 0.15 were more likely to have T3/4 tumors, advanced stage lymphovascular (LVI), or perineural invasion (PNI) and develop recurrent disease. Univariate analysis demonstrated that T-stage, lymph node status, AJCC stage, LVI, PNI, and LNR were significantly associated with decreased time to distant recurrence (TTDR). In multivariate stepwise regression, only LNR and LVI were significantly associated with decreased TTDR.
conclusionsA high positive LNR is associated with distant recurrence after surgical resection of AC. Given the high risk of disease recurrence, consideration for adjuvant therapy is warranted in patients with a LNR ≥ 0.15.
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