ArticleNeurology2012
Neurologic outcomes in retinopathy-negative cerebral malaria survivors.
Article in Neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 60 citations in OpenAlex.
- Bradykinin contributes to vasogenic edema in murine experimental cerebral malaria.The Journal of clinical investigation · 2026Article
- Pathogens of the Human Central Nervous System-the Major Protozoan Parasites and Helminths.Molecular neurobiology · 2026Review
- Electroencephalogram Features Distinguish Cases of Cerebral Malaria Among Malawian Children With Fever and Coma.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Using Electroencephalography to Assess Coma Etiology in Children with Retinopathy-Negative Cerebral Malaria.The American journal of tropical medicine and hygiene · 2025Article
- Intravenous Fluid Bolus Resuscitation Increases Mortality Risk in Malawian Children with Cerebral Malaria.The American journal of tropical medicine and hygiene · 2025Article
- A comprehensive review of cerebral malaria.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Review
- Determinants of retinopathy and short-term neurological outcomes after cerebral malaria.Scientific reports · 2025Article
- Severity of Vessel Color Changes and Macular and Peripheral Whitening in Malarial Retinopathy Are Associated with Higher Total Body and Sequestered Parasite Burdens.Tropical medicine and infectious disease · 2024Article
- MRI-Based Brain Volume Scoring in Cerebral Malaria Is Externally Valid and Applicable to Lower-Resolution Images.AJNR. American journal of neuroradiology · 2024Article
- Post hospital admission blood lactate measurements are associated with mortality but not neurologic morbidity in children with cerebral malaria.Malaria journal · 2024Article
- Loss to Hospital Follow-Up in Pediatric Cerebral Malaria Survivors: A Case-Control Study.The American journal of tropical medicine and hygiene · 2023Article
- Admission Clinical and EEG Features Associated With Mortality and Long-term Neurologic and Cognitive Outcomes in Pediatric Cerebral Malaria.Neurology · 2023Article
- Clinical aspects of malarial retinopathy: a critical review.Pathogens and global health · 2023Review
- Neurological Complications of Malaria.Current neurology and neuroscience reports · 2022Review
- Observational
- Genetics of cerebral malaria: pathogenesis, biomarkers and emerging therapeutic interventions.Cell & bioscience · 2022Review
- Article
- Using EEG in Resource-Limited Areas: Comparing Qualitative and Quantitative Interpretation Methods in Cerebral Malaria.Pediatric neurology · 2022Article
- Pediatric Cerebral Malaria.Current tropical medicine reports · 2021Article
- "We can't handle things we don't know about": perceived neurorehabilitation challenges for Malawian paediatric cerebral malaria survivors.BMC pediatrics · 2020Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
objectivesPatients surviving retinopathy-positive cerebral malaria (CM) are at high risk for the development of epilepsy, developmental disabilities, and behavioral abnormalities. We aimed to establish whether retinopathy-negative CM is also a risk factor for these outcomes.
methodsBetween 2005 and 2007, survivors of CM and concurrently hospitalized controls in Blantyre, Malawi, were followed to assess the development of neurologic abnormalities. At discharge and every 3 months thereafter, incident cases of epilepsy and developmental disabilities were ascertained using screening questionnaires and confirmatory neurologic examinations. Incident cases of epilepsy and developmental disabilities were compared in retinopathy-negative CM survivors to controls and retinopathy-positive CM survivors.
resultsThirty-five retinopathy-negative CM survivors were enrolled. Their neurologic outcomes were compared to 132 retinopathy-positive CM survivors and 272 controls. Compared to survivors of retinopathy-positive CM, children without malaria retinopathy have an equal odds of adverse neurologic outcome (odds ratio [OR] = 1.0, 95% confidence interval [CI] 0.4-2.2). Eleven of 35 survivors of retinopathy-negative CM had at least 1 adverse neurologic outcome compared to 2 of 272 controls (OR 61.9, 95% CI 13.0-295.5). In retinopathy-negative CM survivors, a Blantyre Coma Scale score ≤ 1 on admission was associated with an adverse outcome.
conclusionsCompared with controls, children surviving either retinopathy-negative or -positive CM are at similar high risk for adverse neurologic outcomes. Studies to evaluate preventive and therapeutic strategies in children with both retinopathy-negative and -positive CM are needed to improve mortality, morbidity, or both.
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