SynthesisNeurology2012
Recommendations for optimal ICD codes to study neurologic conditions: a systematic review.
Synthesis in Neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
103 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Shared Genetic Risk Factors for Multiple Sclerosis/Psoriasis Suggest Involvement of Interleukin-17 and Janus Kinase-Signal Transducers and Activators of Transcription Signaling.Annals of neurology · 2023Pooled it
- Validity of International Classification of Diseases Codes for Identifying Neuro-Ophthalmic Disease in Large Data Sets: A Systematic Review.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2020Pooled it
- Identifying dementia cases with routinely collected health data: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Pooled it
- Epidemiology of recurrent traumatic brain injury in the general population: A systematic review.Neurology · 2017Pooled it
- Validity of administrative data in recording sepsis: a systematic review.Critical care (London, England) · 2015Pooled it
- Defining pediatric traumatic brain injury using International Classification of Diseases Version 10 Codes: a systematic review.BMC neurology · 2015Pooled it
- Weight Loss Associated with Cholinesterase Inhibitors in Individuals with Dementia in a National Healthcare System.Journal of the American Geriatrics Society · 2015Trial
- Severe head injury and amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2013Trial
- Analysis of Health-Related Quality of Life in Multiple Sclerosis: A Bayesian Quantile LASSO Approach.Healthcare (Basel, Switzerland) · 2026Article
- Influence of Enhanced Administrative Case-Finding Strategies on Prevalence of Hypertensive Disorders of Pregnancy in Ontario: A Population-Based Descriptive Study.Journal of the American Heart Association · 2026Article
- Perioperative Best Practices and Delirium in Patients With Cognitive Impairment.JAMA network open · 2026Observational
- Characteristics associated with first anti-seizure medication prescribed in a cohort of adults with newly diagnosed epilepsy.Seizure · 2026Article
- Mapping Clinical Intent in Internet Hospitals: Identifying and Profiling Patient Demand via Natural Language Processing.Computational and structural biotechnology journal · 2026Article
- Associations between traumatic brain injury and the prevalence of Alzheimer's disease dementia and behavioral and psychological symptoms of dementia: A retrospective cohort study.The journal of prevention of Alzheimer's disease · 2026Article
- Spatio-temporal patterns of neurodegenerative disease hospitalizations in mainland Portugal.Frontiers in public health · 2026Article
- Prevalence of multiple sclerosis and disease-modifying therapy use in older adults in the United States, 2011-2021.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Article
- Large-scale seroepidemiology uncovers nephro-urological pathologies in people with tau autoimmunity.PLoS biology · 2025Article
- The Burden of Motor Neuron Diseases in the United States, 1990-2021: A Systematic Analysis of the Global Burden of Disease Study 2021.Muscle & nerve · 2025Article
- Insurance type and risk of dementia diagnosis after traumatic brain injury: a study of 267 473 US civilians from 2000 to 2022.BMJ open · 2025Article
- Dual-stream algorithms for dementia detection: Harnessing structured and unstructured electronic health record data, a novel approach to prevalence estimation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectiveAdministrative health data are frequently used for large population-based studies. However, the validity of these data for identifying neurologic conditions is uncertain.
methodsThis article systematically reviews the literature to assess the validity of administrative data for identifying patients with neurologic conditions. Two reviewers independently assessed for eligibility all abstracts and full-text articles identified through a systematic search of Medline and Embase. Study data were abstracted on a standardized abstraction form to identify ICD code-based case definitions and corresponding sensitivity, specificity, positive predictive values (PPVs), and negative predictive values (NPVs).
resultsThirty full-text articles met the eligibility criteria. These included 8 studies for Alzheimer disease/dementia (sensitivity: 8-86.5, specificity: 56.3-100, PPV: 60-97.9, NPV: 68.0-98.9), 2 for brain tumor (sensitivity: 54.0-100, specificity: 97.0-99.0, PPV: 91.0-98.0), 4 for epilepsy (sensitivity: 98.8, specificity: 69.6, PPV: 62.0-100, NPV: 89.5-99.1), 4 for motor neuron disease (sensitivity: 78.9-93.0, specificity: 99.0-99.9, PPV: 38.0-90.0, NPV: 99), 2 for multiple sclerosis (sensitivity: 85-92.4, specificity: 55.9-92.6, PPV: 74.5-92.7, NPV: 70.8-91.9), 4 for Parkinson disease/parkinsonism (sensitivity: 18.7-100, specificity: 0-99.9, PPV: 38.6-81.0, NPV: 46.0), 3 for spinal cord injury (sensitivity: 0.9-90.6, specificity: 31.9-100, PPV: 27.3-100), and 3 for traumatic brain injury (sensitivity: 45.9-78.0 specificity: 97.8, PPV: 23.7-98.0, NPV: 99.2). No studies met eligibility criteria for cerebral palsy, dystonia, Huntington disease, hydrocephalus, muscular dystrophy, spina bifida, or Tourette syndrome.
conclusionsTo ensure the accurate interpretation of population-based studies with use of administrative health data, the accuracy of case definitions for neurologic conditions needs to be taken into consideration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.