ArticleAmerican journal of physiology. Renal physiology2012
Melanocortin antagonism ameliorates muscle wasting and inflammation in chronic kidney disease.
Article in American journal of physiology. Renal physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 46 citations in OpenAlex.
- Immunoregulation in cancer-associated cachexia.Journal of advanced research · 2024Review
- Comparison of the effects of different calorie amounts of enteral nutrition in hypercatabolism associated with ghrelin-POMC in endotoxemic rats.Nutrition & metabolism · 2022Article
- Pathophysiological mechanisms leading to muscle loss in chronic kidney disease.Nature reviews. Nephrology · 2022Review
- Pharmacokinetics and safety of TCMCB07, a melanocortin-4 antagonist peptide in dogs.Pharmacology research & perspectives · 2021Article
- Melanocortin-4 receptor antagonist TCMCB07 ameliorates cancer- and chronic kidney disease-associated cachexia.The Journal of clinical investigation · 2020Article
- Late onset obesity in mice with targeted deletion of potassium inward rectifier Kir7.1 from cells expressing the melanocortin-4 receptor.Journal of neuroendocrinology · 2019Article
- Inter-tissue communication in cancer cachexia.Nature reviews. Endocrinology · 2018Review
- Role of the brain melanocortins in blood pressure regulation.Biochimica et biophysica acta. Molecular basis of disease · 2017Review
- Article
- Hypothalamic activation is essential for endotoxemia-induced acute muscle wasting.Scientific reports · 2016Article
- An Intronic Enhancer Element Regulates Angiotensin II Type 2 Receptor Expression during Satellite Cell Differentiation, and Its Activity Is Suppressed in Congestive Heart Failure.The Journal of biological chemistry · 2016Article
- Lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNFα) blunt the response of Neuropeptide Y/Agouti-related peptide (NPY/AgRP) glucose inhibited (GI) neurons to decreased glucose.Brain research · 2016Article
- Impaired regeneration: A role for the muscle microenvironment in cancer cachexia.Seminars in cell & developmental biology · 2016Review
- Inflammation and nutrition in children with chronic kidney disease.World journal of nephrology · 2016Review
- Muscle wasting and adipose tissue browning in infantile nephropathic cystinosis.Journal of cachexia, sarcopenia and muscle · 2016Article
- Uninephrectomy-Induced Lipolysis and Low-Grade Inflammation Are Mimicked by Unilateral Renal Denervation.Frontiers in physiology · 2016Article
- Skeletal Muscle Regeneration and Oxidative Stress Are Altered in Chronic Kidney Disease.PloS one · 2016Article
- Uninephrectomy in Rats on a Fixed Food Intake Potentiates Both Anorexia and Circulating Cytokine Subsets in Response to LPS.Frontiers in immunology · 2015Article
- Nonmuscle Tissues Contribution to Cancer Cachexia.Mediators of inflammation · 2015Review
- Uninephrectomy in rats on a fixed food intake results in adipose tissue lipolysis implicating spleen cytokines.Frontiers in physiology · 2015Article
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2 authors at 1 institution in 1 country.
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Abstract
Aberrant melanocortin signaling has been implicated in the pathogenesis of wasting in chronic kidney disease (CKD). Previously, we demonstrated that agouti-related peptide (AgRP), a melenocortin-4 receptor antagonist, reduced CKD-associated cachexia in CKD mice. Our previous studies with AgRP utilized dual energy X-ray (DXA) densitometry to assess the body composition in mice (Cheung W, Kuo HJ, Markison S, Chen C, Foster AC, Marks DL, Mak RH. J Am Soc Nephrol 18: 2517-2524, 2007; Cheung W, Yu PX, Little BM, Cone RD, Marks DL, Mak RH. J Clin Invest 115: 1659-1665, 2005). DXA is unable to differentiate water content in mice, and fluid retention in CKD may lead to an overestimate of lean mass. In this study, we employed quantitative magnetic resonance technique to evaluate body composition change following central administration of AgRP in a CKD mouse model. AgRP treatment improved energy expenditure, total body mass, fat mass, and lean body mass in CKD mouse. We also investigated the effect of CKD-associated cachexia on the signaling pathways leading to wasting in skeletal muscle, as well as whether these changes can be ameliorated by central administration of AgRP. AgRP treatment caused an overall decrease in proinflammatory cytokines, which may be one important mechanism of its effects. Muscle wasting in CKD may be due to the activation of proteolytic pathways as well as inhibition of myogenesis and muscle regeneration processes. Our results suggest that these aberrant pathological pathways leading to muscle wasting in CKD mice were ameliorated by central administration of AgRP.
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