ArticleJournal of clinical gastroenterology2013
Diverging trends in the incidence of reflux-related and Helicobacter pylori-related gastric cardia cancer.
Article in Journal of clinical gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Chemotherapy for advanced gastric cancer.The Cochrane database of systematic reviews · 2017Pooled it
- Comparison of Claudin 18.2 expression in primary tumors and lymph node metastases in Japanese patients with gastric adenocarcinoma.Japanese journal of clinical oncology · 2019Trial
- Poorer prognosis of early gastric cardia cancer compared to early gastric non-cardia cancer: evidence from SEER database analysis.Journal of gastrointestinal oncology · 2025Article
- Targeting PI3K/AKT/mTOR and MAPK Signaling Pathways in Gastric Cancer.International journal of molecular sciences · 2024Review
- Better prognosis of gastric cancer patients with high levels of tumor infiltrating lymphocytes is counteracted by PD-1 expression.Oncoimmunology · 2020Article
- Risk factors associated with gastric malignancy during chronicMedical research archives · 2020Article
- What is the Relevance of Gastric Microbiota Beyond H. pylori?Current treatment options in gastroenterology · 2019Review
- Analyses on K-ras mutations and fascin expression in patients with cardia cancer.Oncology letters · 2019Article
- Epidemiology of gastric cancer: global trends, risk factors and prevention.Przeglad gastroenterologiczny · 2019Review
- The inflammatory potential of diet in determining cancer risk; A prospective investigation of two dietary pattern scores.PloS one · 2019Article
- The role of the gastric bacterial microbiome in gastric cancer:Therapeutic advances in gastroenterology · 2019Review
- Importance of tumor location and histology in familial risk of upper gastrointestinal cancers: a nationwide cohort study.Clinical epidemiology · 2018Article
- Oesophageal adenocarcinoma and gastric cancer: should we mind the gap?Nature reviews. Cancer · 2016Review
- IL-1RT1 signaling antagonizes IL-11 induced STAT3 dependent cardiac and antral stomach tumor development through myeloid cell enrichment.Oncotarget · 2015Article
- Article
- Ethnic disparities in gastric cancer incidence and survival in the USA: an updated analysis of 1992-2009 SEER data.Digestive diseases and sciences · 2014Article
- Article
- Cure Is Possible: Extensively Metastatic HER2-Positive Gastric Carcinoma with 5 years of Complete Remission after Therapy with the FLOT Regimen and Trastuzumab.Case reports in gastroenterologyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
goalsTo describe historical incidence trends of 2 subtypes of gastric cardia cancer.
backgroundThe incidence of gastric cardia cancer has increased in western countries. Prior studies have treated cardia cancer as a single entity, but recent data suggest that there are 2 distinct subtypes: reflux-related and Helicobacter pylori-related. STUDY: We conducted a population-based study using Connecticut Tumor Registry data from 1955 to 2007. Age-adjusted incidence rates (per 100,000 person-years) were calculated for gastric cancer, as a whole and by anatomic subsite, and for esophageal adenocarcinoma. Cardia and noncardia cancer incidence rates were further adjusted to account for cases with unspecified subsite. Mathematical formulas were derived to calculate incidence rates for reflux-related and H. pylori-related cardia cancer.
resultsThe adjusted incidence of cardia cancer was 4.0 per 100,000 in 1955 to 1959, decreased to 2.4 per 100,000 in 1965 to 1969 before increasing to 3.4 per 100,000 by 2003 to 2007. The incidence of H. pylori-related cardia cancer decreased from 3.7 to 1.0 per 100,000 over the study period, whereas reflux-related cardia cancer increased progressively from 0.3 to 2.4 per 100,000. The curves for reflux-related cardia cancer and esophageal adenocarcinoma closely mirrored each other, and their combined incidence increased from 0.5 per 100,000 in 1955 to 1959 to 5.6 per 100,000 in 2003 to 2007.
conclusionsThe incidence of reflux-related cardia cancer has steadily increased, whereas H. pylori-related cardia cancer has declined progressively since the mid-20th century. Trends in reflux-related cardia cancer and esophageal adenocarcinoma incidence are very similar, suggesting that these 2 cancers share a similar etiology and pathophysiological process.
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