ArticleBehavioural pharmacology2012
Environmental enrichment during development decreases intravenous self-administration of methylphenidate at low unit doses in rats.
Article in Behavioural pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- Psychoactive substances: novel molecular insights and therapeutic potential for Alzheimer's disease.Translational neurodegeneration · 2025Review
- A bibliometric analysis of studies on environmental enrichment spanning 1967-2024: patterns and trends over the years.Frontiers in behavioral neuroscience · 2024Article
- Neurobehavioral effects of environmental enrichment and drug abuse vulnerability: An updated review.Pharmacology, biochemistry, and behavior · 2022Review
- Early environmental enrichment and impoverishment differentially affect addiction-related behavioral traits, cocaine-taking, and dopamine DPsychopharmacology · 2021Article
- Incubation of Oxycodone Craving Following Adult-Onset and Adolescent-Onset Oxycodone Self-Administration in Male Rats.Frontiers in behavioral neuroscience · 2021Article
- Opposite regulation of conditioned place preference and intravenous drug self-administration in rodent models: Motivational and non-motivational examples.Neuroscience and biobehavioral reviews · 2020Review
- Biological intersection of sex, age, and environment in the corticotropin releasing factor (CRF) system and alcohol.Neuropharmacology · 2020Review
- Histone deacetylase inhibition differentially attenuates cue-induced reinstatement: An interaction of environment and acH3K9 expression in the dorsal striatum.Behavioral neuroscience · 2019Article
- Environmental enrichment and drug value: a behavioral economic analysis in male rats.Addiction biology · 2019Article
- Modified single prolonged stress reduces cocaine self-administration during acquisition regardless of rearing environment.Behavioural brain research · 2018Article
- Effects of environmental enrichment on self-administration of the short-acting opioid remifentanil in male rats.Psychopharmacology · 2017Article
- Effects of environmental enrichment on d-amphetamine self-administration following nicotine exposure.Experimental and clinical psychopharmacology · 2017Article
- Effects of dopamine D1 and D2 receptor agonists on environmental enrichment attenuated sucrose cue reactivity in rats.Psychopharmacology · 2017Article
- Transcriptomics of Environmental Enrichment Reveals a Role for Retinoic Acid Signaling in Addiction.Frontiers in molecular neuroscience · 2016Article
- Environmental condition alters amphetamine self-administration: role of the MGluR₅ receptor and schedule of reinforcement.Psychopharmacology · 2015Article
- One day access to a running wheel reduces self-administration of D-methamphetamine, MDMA and methylone.Drug and alcohol dependence · 2015Article
- Pharmacological manipulation of glucocorticoid receptors differentially affects cocaine self-administration in environmentally enriched and isolated rats.Behavioural brain research · 2015Article
- Inoculation stress hypothesis of environmental enrichment.Neuroscience and biobehavioral reviews · 2015Review
- Effects of environmental enrichment on ERK1/2 phosphorylation in the rat prefrontal cortex following nicotine-induced sensitization or nicotine self-administration.The European journal of neuroscience · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Despite the efficacy and widespread use of methylphenidate (MPH) as a treatment modality for attention deficit hyperactivity disorder, clinical and preclinical findings indicate that it has abuse potential. Environmental enrichment reduces susceptibility to cocaine and amphetamine self-administration and decreases impulsive behavior, but its effects on MPH self-administration are unknown. The present experiments sought to determine the influence of environmental enrichment on MPH self-administration. Male rats were raised in an enriched condition (EC) or isolated condition (IC). They were trained to self-administer MPH (0.3 mg/kg/infusion) and then exposed to varying doses of MPH on either a fixed-ratio (experiment 1) or a progressive-ratio (experiment 2) schedule of reinforcement. EC rats earned significantly fewer infusions of MPH at low doses (0.03 and 0.056 mg/kg/infusion) compared with IC rats under both schedules; however, no differences were observed at high unit doses (0.1-1.0 mg/kg/infusion). During saline substitution at the end of MPH self-administration, EC rats also responded less for saline compared with IC rats, indicative of more rapid extinction. As with other stimulant drugs with different mechanisms of action, environmental enrichment during development protects against self-administration of MPH at low unit doses but not at high unit doses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.