ArticleJournal of immunology (Baltimore, Md. : 1950)2012
p40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation.
Article in Journal of immunology (Baltimore, Md. : 1950), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.Nature genetics · 2015Pooled it
- Article
- NCF4 attenuates colorectal cancer progression by modulating inflammasome activation and immune surveillance.Nature communications · 2024Article
- Neutrophil Extracellular Trap Density Increases With Increasing Histopathological Severity of Crohn's Disease.Inflammatory bowel diseases · 2022Article
- Role of p40FEBS open bio · 2021Article
- From Flies to Men: ROS and the NADPH Oxidase in Phagocytes.Frontiers in cell and developmental biology · 2021Review
- TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Muc5ac Expression Protects the Colonic Barrier in Experimental Colitis.Inflammatory bowel diseases · 2020Article
- Dual immune functions of IL-33 in inflammatory bowel disease.Histology and histopathology · 2020Review
- Inherited p40phox deficiency differs from classic chronic granulomatous disease.The Journal of clinical investigation · 2018Article
- NADPH oxidases and ROS signaling in the gastrointestinal tract.Mucosal immunology · 2018Review
- Clinical and Genomic Correlates of Neutrophil Reactive Oxygen Species Production in Pediatric Patients With Crohn's Disease.Gastroenterology · 2018Article
- The effect of the SNP g.18475 A>G in the 3'UTR of NCF4 on mastitis susceptibility in dairy cattle.Cell stress & chaperones · 2018Article
- Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo.Scientific reports · 2017Article
- ROS in gastrointestinal inflammation: Rescue Or Sabotage?British journal of pharmacology · 2017Review
- p40Frontiers in immunology · 2017Article
- Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance.Frontiers in cellular and infection microbiology · 2017Review
- Immunometabolism and autoimmunity.Immunology and cell biology · 2016Review
- Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes.Diabetes · 2015Article
- Genetic disorders coupled to ROS deficiency.Redox biology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
NADPH oxidase is a multisubunit complex that assembles during phagocytosis to generate reactive oxygen species. Several components of this complex have been implicated in chronic granulomatous disease and Crohn's disease, highlighting the importance of reactive oxygen species in regulating host immune response. In this study, we use genetically deficient mice to elucidate how p40(phox), one subunit of the NADPH oxidase complex, functions during intestinal inflammation. We show that p40(phox) deficiency enhances inflammation in both dextran sulfate sodium-induced and innate immune-mediated murine colitis models. This inflammation is characterized by severe colonic tissue injury, increased proinflammatory cytokines, and increased neutrophil recruitment. We demonstrate that neutrophils are essential during the recovery phase of intestinal inflammation and that p40(phox) expression is necessary for this restitution. Lastly, using an integrative bioinformatic approach, we show that p40(phox) deficiency leads to upregulation of chemokine receptor 1 and downregulation of enzymes involved in glycan modifications, including fucosyltransferases and sialyltransferases, during inflammation. We propose that p40(phox) deficiency enhances intestinal inflammation through the dysregulation of these two pathways in neutrophils.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.