ArticleJournal of the American Chemical Society2012
Bioelectrochemical switches for the quantitative detection of antibodies directly in whole blood.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 107 citations in OpenAlex.
- Rationally Designed DNA-Based Scaffolds and Switching Probes for Protein Sensing.Advances in biochemical engineering/biotechnology · 2024Review
- Synthetic Antigen-Conjugated DNA Systems for Antibody Detection and Characterization.ACS sensors · 2023Review
- Ionic Strength and Hybridization Position near Gold Electrodes Can Significantly Improve Kinetics in DNA-Based Electrochemical Sensors.ACS applied materials & interfaces · 2023Article
- Recent progress and perspectives of continuous in vivo testing device.Materials today. Bio · 2022Review
- Silver Nanocubes as Electrochemical Labels for Bioassays.ACS sensors · 2021Article
- Recent Developments of Electrochemical and Optical Biosensors for Antibody Detection.International journal of molecular sciences · 2019Review
- Nonfaradaic Current Suppression in DNA-Based Electrochemical Assays with a Differential Potentiostat.Analytical chemistry · 2019Article
- High frequency, calibration-free molecular measurementsChemical science · 2019Article
- A Biomimetic Phosphatidylcholine-Terminated Monolayer Greatly Improves the In Vivo Performance of Electrochemical Aptamer-Based Sensors.Angewandte Chemie (International ed. in English) · 2017Article
- Selective Removal of Hemoglobin from Blood Using Hierarchical Copper Shells Anchored to Magnetic Nanoparticles.BioMed research international · 2017Article
- Accurate Quantitative Sensing of Intracellular pH based on Self-ratiometric Upconversion Luminescent Nanoprobe.Scientific reports · 2016Article
- A Paper-Based "Pop-up" Electrochemical Device for Analysis of Beta-Hydroxybutyrate.Analytical chemistry · 2016Article
- Activity modulation and allosteric control of a scaffolded DNAzyme using a dynamic DNA nanostructure.Chemical science · 2016Article
- A Modular, DNA-Based Beacon for Single-Step Fluorescence Detection of Antibodies and Other Proteins.Angewandte Chemie (International ed. in English) · 2015Article
- A reusable electrochemical proximity assay for highly selective, real-time protein quantitation in biological matrices.Journal of the American Chemical Society · 2014Article
- Saliva-based biosensors: noninvasive monitoring tool for clinical diagnostics.BioMed research international · 2014Review
- Digital imprinting of RNA recognition and processing on a self-assembled nucleic acid matrix.Scientific reports · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
Abstract
The development of rapid, low-cost point-of-care approaches for the quantitative detection of antibodies would drastically impact global health by shortening the delay between sample collection and diagnosis and by improving the penetration of modern diagnostics into the developing world. Unfortunately, however, current methods for the quantitative detection of antibodies, including ELISAs, Western blots, and fluorescence polarization assays, are complex, multiple-step processes that rely on well-trained technicians working in well-equipped laboratories. In response, we describe here a versatile, DNA-based electrochemical "switch" for the rapid, single-step measurement of specific antibodies directly in undiluted whole blood at clinically relevant low-nanomolar concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.