ArticleACS combinatorial science2012
A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries.
Article in ACS combinatorial science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Positional Scanning MUC1 Glycopeptide Library Reveals the Importance of PDTR Epitope Glycosylation for Lectin Binding.The Journal of organic chemistry · 2020Article
- Dissecting MMP PThe Journal of biological chemistry · 2018Article
- Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries.Molecular pharmacology · 2013Article
- Libraries from Libraries: A Series of Sulfonamide Linked Heterocycles Derived from the Same Scaffold.Tetrahedron letters · 2013Article
- The mathematics of a successful deconvolution: a quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptors.Molecules (Basel, Switzerland) · 2013Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
A novel method for the direct evaluation of the equimolarity of the compounds contained in a mixture is presented. We applied the method toward calculating isokinetic ratios for the reaction between the amine termini of a resin bound peptide fragment and a sulfonyl chloride to produce equal molar mixtures of sulfonamides. The results of this study and the application of the method to the synthesis of two new positional scanning synthetic combinatorial libraries (PS-SCL) are discussed.
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Registered trials
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