ArticleBiology direct2012
Does the central dogma still stand?
Article in Biology direct, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 73 citations in OpenAlex.
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- "Molecular Biology"-Pleonasm or Denotation for a Discipline of Its Own? Reflections on the Origins of Molecular Biology and Its Situation Today.Biomolecules · 2023Review
- Plant translational reprogramming for stress resilience.Frontiers in plant science · 2023Review
- Potential and Metabolic Pathways of Eugenol in the Management ofInternational journal of molecular sciences · 2022Article
- Glycobiology of Cancer: Sugar Drives the Show.Medicines (Basel, Switzerland) · 2022Article
- The remodel of the "central dogma": a metabolomics interaction perspective.Metabolomics : Official journal of the Metabolomic Society · 2021Review
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- The Boscombe Valley mystery: A lesson in the perils of dogmatism in science.Journal of biosciences · 2021Article
- Connecting primitive phase separation to biotechnology, synthetic biology, and engineering.Journal of biosciences · 2021Review
- What are the principles that govern life?Communicative & integrative biology · 2020Article
- Multiview learning for understanding functional multiomics.PLoS computational biology · 2020Review
- Genomic clustering within functionally related gene families inComputational and structural biotechnology journal · 2020Review
- State of the Field in Multi-Omics Research: From Computational Needs to Data Mining and Sharing.Frontiers in genetics · 2020Review
- Reduced Abundance and Subverted Functions of Proteins in Prion-Like Diseases: Gained Functions Fascinate but Lost Functions Affect Aetiology.International journal of molecular sciences · 2017Review
- Epigenetic inheritance, prions and evolution.Journal of genetics · 2017Review
- Structural signatures of thermal adaptation of bacterial ribosomal RNA, transfer RNA, and messenger RNA.PloS one · 2017Article
- Just how Lamarckian is CRISPR-Cas immunity: the continuum of evolvability mechanisms.Biology direct · 2016Article
- Why the Central Dogma: on the nature of the great biological exclusion principle.Biology direct · 2015Article
- Article
- The Lamarckian chicken and the Darwinian egg.Biology direct · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Prions are agents of analog, protein conformation-based inheritance that can confer beneficial phenotypes to cells, especially under stress. Combined with genetic variation, prion-mediated inheritance can be channeled into prion-independent genomic inheritance. Latest screening shows that prions are common, at least in fungi. Thus, there is non-negligible flow of information from proteins to the genome in modern cells, in a direct violation of the Central Dogma of molecular biology. The prion-mediated heredity that violates the Central Dogma appears to be a specific, most radical manifestation of the widespread assimilation of protein (epigenetic) variation into genetic variation. The epigenetic variation precedes and facilitates genetic adaptation through a general 'look-ahead effect' of phenotypic mutations. This direction of the information flow is likely to be one of the important routes of environment-genome interaction and could substantially contribute to the evolution of complex adaptive traits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.