ArticlePloS one2012
IAA8 involved in lateral root formation interacts with the TIR1 auxin receptor and ARF transcription factors in Arabidopsis.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 97 citations in OpenAlex.
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- Signatures in domesticated beet genomes pointing at genes under selection in a sucrose-storing root crop.BMC biology · 2025Article
- PtrIAA12-PtrARF8 Complex Regulates the Expression ofPlants (Basel, Switzerland) · 2025Article
- Overexpression of Auxin/Indole-3-Acetic Acid Gene TrIAA27 Enhances Biomass, Drought, and Salt Tolerance inPlants (Basel, Switzerland) · 2024Article
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- Genome-Wide Identification and Analysis of the Aux/IAA Gene Family inInternational journal of molecular sciences · 2024Article
- AtSNP_TATAdb: Candidate Molecular Markers of Plant Advantages Related to Single Nucleotide Polymorphisms within Proximal Promoters ofInternational journal of molecular sciences · 2024Article
- A non-canonicalFrontiers in plant science · 2024Article
- Genome-wide identification and expression analysis of the AUX/IAA gene family in turnip (Brassica rapa ssp. rapa).BMC plant biology · 2023Article
- Construction of heat stress regulation networks based on Illumina and SMRT sequencing data in potato.Frontiers in plant science · 2023Article
- Transcription Factor IAA27 Positively Regulates P Uptake through Promoted Adventitious Root Development in Apple Plants.International journal of molecular sciences · 2022Article
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- Analysis of the Transcriptional Dynamics of Regulatory Genes During Peanut Pod Development Caused by Darkness and Mechanical Stress.Frontiers in plant science · 2022Article
- Identification and characterization of auxin response factor (ARF) family members involved in fig (PeerJ · 2022Article
- Role of Auxin and Nitrate Signaling in the Development of Root System Architecture.Frontiers in plant science · 2021Review
- Comparative Transcriptome Analysis of Iron and Zinc Deficiency in Maize (Plants (Basel, Switzerland) · 2020Article
- A de novo transcriptome analysis revealed that photomorphogenic genes are required for carotenoid synthesis in the dark-grown carrot taproot.Molecular genetics and genomics : MGG · 2020Article
- Genome-wide characterization and expression analyses of the auxin/indole-3-acetic acid (Aux/IAA) gene family in barley (Hordeum vulgare L.).Scientific reports · 2020Article
- Drought-induced protein (Di19-3) plays a role in auxin signaling by interacting with IAA14 in Arabidopsis.Plant direct · 2020Article
- Transcription factors as molecular switches to regulate drought adaptation in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of auxin-responsive genes is regulated by the TIR1/AFB auxin receptor-dependent degradation of Aux/IAA transcriptional repressors, which interact with auxin-responsive factors (ARFs). Most of the 29 Aux/IAA genes present in Arabidopsis have not been functionally characterized to date. IAA8 appears to have a distinct function from the other Aux/IAA genes, due to its unique transcriptional response to auxin and the stability of its encoded protein. In this study, we characterized the function of Arabidopsis IAA8 in various developmental processes governed by auxin and in the transcriptional regulation of the auxin response. Transgenic plants expressing estrogen-inducible IAA8 (XVE::IAA8) exhibited significantly fewer lateral roots than the wild type, and an IAA8 loss-of-function mutant exhibited significantly more. Ectopic overexpression of IAA8 resulted in abnormal gravitropism. The strong induction of early auxin-responsive marker genes by auxin treatment was delayed by IAA8 overexpression. GFP-fusion analysis revealed that IAA8 localized not only to the nucleus, but, in contrast to other Aux/IAAs, also to the cytosol. Furthermore, we demonstrated that IAA8 interacts with TIR1, in an auxin-dependent fashion, and with ARF proteins, both in yeast and in planta. Taken together, our results show that IAA8 is involved in lateral root formation, and that this process is regulated through the interaction with the TIR1 auxin receptor and ARF transcription factors in the nucleus.
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