SynthesisPloS one2012
C-reactive protein, interleukin 6 and lung cancer risk: a meta-analysis.
Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Prognostic Value of Glasgow Prognostic Score in Non-small Cell Lung Cancer: A Systematic Review and Meta-Analysis.Pathology oncology research : POR · 2022Pooled it
- Genetic polymorphisms in C-reactive protein increase cancer susceptibility.Scientific reports · 2016Pooled it
- Lack of association between a functional polymorphism (rs1800796) in the interleukin-6 gene promoter and lung cancer.Diagnostic pathology · 2014Pooled it
- Bidirectional Mendelian randomization identifies differential causal associations between inflammatory cytokines and lung cancer subtypes.Discover oncology · 2026Article
- Inflammatory cytokines and specific factors influencing lung cancer progression.Cancer pathogenesis and therapy · 2025Review
- Association of urinary arsenic concentrations with inflammation: overall and by folate intake, body mass index, and gender.International journal of hygiene and environmental health · 2025Article
- A novel prediction model for the prognosis of non-small cell lung cancer with clinical routine laboratory indicators: a machine learning approach.BMC medical informatics and decision making · 2024Article
- Genetic correlation and causal associations between circulating C-reactive protein levels and lung cancer risk.Cancer causes & control : CCC · 2024Article
- Combining Classic and Novel Neutrophil-Related Biomarkers to Identify Non-Small-Cell Lung Cancer.Cancers · 2024Article
- Integrating genomics and proteomics data to identify candidate plasma biomarkers for lung cancer risk among European descendants.British journal of cancer · 2023Article
- Clinical and biological risk factors associated with inflammation in patients with type 2 diabetes mellitus.BMC endocrine disorders · 2022Article
- Ageing-related markers and risks of cancer and cardiovascular disease: a prospective study in the EPIC-Heidelberg cohort.European journal of epidemiology · 2022Article
- Social media use and systemic inflammation: The moderating role of self-esteem.Brain, behavior, & immunity - health · 2021Article
- Prospective Identification of Elevated Circulating CDCP1 in Patients Years before Onset of Lung Cancer.Cancer research · 2021Article
- Role of pretreatment inflammatory indicators in pediatric acute leukemias; where do we stand? A prospective cohort study.Cancer biomarkers : section A of Disease markers · 2020Article
- Association of inflammatory biomarkers with lung cancer in North Indian population.African health sciences · 2019Article
- Predictive value of inflammatory markers for cancer diagnosis in primary care: a prospective cohort study using electronic health records.British journal of cancer · 2019Article
- Chronic inflammation and risk of lung cancer in older adults in the health, aging and body composition cohort study.Journal of geriatric oncology · 2019Article
- Comparison of the Prognostic Value of Systemic Inflammation Response Markers in Small Cell Lung Cancer Patients.Journal of Cancer · 2019Article
- [Research progress on interleukin-6 in lung cancer].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEpidemiologic findings are inconsistent concerning the associations between C-reactive protein (CRP), interleukin 6 (IL-6) and lung cancer risk. We conducted a meta-analysis of epidemiologic studies to examine these associations.
methodsA systematic literature search up to October 2011 was performed in MEDLINE and EMBASE. Study-specific risk estimates were pooled using a random-effects model.
resultsThe 10 studies on CRP involved a total of 1918 lung cancer cases. The pooled RR of lung cancer for one unit change in natural logarithm (ln) CRP was 1.28 (95% CI 1.17-1.41). There was no statistically significant heterogeneity among studies (P = 0.116; I(2) = 36.6%). We also found that CRP was significantly associated with increased risk of lung cancer among men (RR 1.18, 95% CI 1.09-1.28) but not among women. The 5 studies on IL-6 involved a total of 924 lung cancer cases. The pooled RR of lung cancer for one unit change in ln IL-6 was 1.28 (95% CI 0.92-1.79), however, statistically significant heterogeneity was found. After excluding the study contributing most to the heterogeneity, the summary estimate was essentially unchanged.
conclusionCRP was associated with increased risk of lung cancer, especially among men. There was no significant association between IL-6 and lung cancer risk.
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