ArticlePloS one2012
Rana grylio virus (RGV) 50L is associated with viral matrix and exhibited two distribution patterns.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Replication and transcription machinery for ranaviruses: components, correlation, and functional architecture.Cell & bioscience · 2022Article
- A transmembrane domain of3 Biotech · 2019Article
- Ranaviruses Bind Cells from Different Species through Interaction with Heparan Sulfate.Viruses · 2019Article
- Article
- Article
- Divergent transcriptomic responses underlying the ranaviruses-amphibian interaction processes on interspecies infection of Chinese giant salamander.BMC genomics · 2018Article
- Genome architecture changes and major gene variations of Andrias davidianus ranavirus (ADRV).Veterinary research · 2013Article
- Evidence for Paralichthys olivaceus IFITM1 antiviral effect by impeding viral entry into target cells.Fish & shellfish immunology · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe complete genome of Rana grylio virus (RGV) was sequenced and analyzed recently, which revealed that RGV 50 L had homologues in many iridoviruses with different identities; however, the characteristics and functions of 50 L have not been studied yet. METHODOLOGY/PRINCIPAL
findingsWe cloned and characterized RGV50L, and revealed 50 L functions in virus assembly and gene regulation. 50 L encoded a 499-amino acid structural protein of about 85 kDa in molecular weight and contained a nuclear localization signal (NLS) and a helix- extension-helix motif. Drug inhibition assay demonstrated that 50 L was an immediate-early (IE) gene. Immuno-fluorescence assay revealed that 50 L appeared early and persisted in RGV-infected cells following two distribution patterns. One pattern was that 50 L exhibited a cytoplasm-nucleus- viromatrix distribution pattern, and mutagenesis of the NLS motif revealed that localization of 50 L in the nucleus was NLS-dependent; the other was that 50 L co-localized with viral matrix which plays important roles in virus assembly and the life circle of viruses. CONCLUSIONS/SIGNIFICANCE: RGV 50L is a novel iridovirus IE gene encoded structural protein which plays important roles in virus assembly.
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