ArticlePloS one2012
Open source tracking and analysis of adult Drosophila locomotion in Buridan's paradigm with and without visual targets.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 109 citations in OpenAlex.
- Individuality across environmental context ineLife · 2026Article
- Dietary Interventions Modulate Cell Competition and Locomotor Decline in an Alzheimer's DiseaseCells · 2025Article
- Temporal transcriptional regulation of mitochondrial morphology primes activity-dependent circuit connectivity.Nature communications · 2025Article
- A New Behavioral Paradigm for Visual Classical Conditioning inBio-protocol · 2023Article
- DVT: a high-throughput analysis pipeline for locomotion and social behavior in adult Drosophila melanogaster.Cell & bioscience · 2023Article
- Numerical discrimination in Drosophila melanogaster.Cell reports · 2023Article
- Responses of different Drosophila species to temperature changes.The Journal of experimental biology · 2022Article
- Article
- Assessing olfactory, memory, social and circadian phenotypes associated with schizophrenia in a genetic model based on Rim.Translational psychiatry · 2021Article
- Nicotine suppresses Parkinson's disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels.Scientific reports · 2021Article
- Sensitivity to expression levels underlies differential dominance of a putative null allele of the Drosophila tβh gene in behavioral phenotypes.PLoS biology · 2021Article
- Article
- A Paradoxical Kind of Sleep in Drosophila melanogaster.Current biology : CB · 2021Article
- Behavior Individuality: A Focus onFrontiers in physiology · 2021Review
- Collective action or individual choice: Spontaneity and individuality contribute to decision-making in Drosophila.PloS one · 2021Article
- Article
- Identification ofOpen biology · 2020Article
- Down-regulation of a cytokine secreted from peripheral fat bodies improves visual attention while reducing sleep in Drosophila.PLoS biology · 2020Article
- The 18S ribosomal RNA mEMBO reports · 2020Article
- Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring.Nature communications · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInsects have been among the most widely used model systems for studying the control of locomotion by nervous systems. In Drosophila, we implemented a simple test for locomotion: in Buridan's paradigm, flies walk back and forth between two inaccessible visual targets [1]. Until today, the lack of easily accessible tools for tracking the fly position and analyzing its trajectory has probably contributed to the slow acceptance of Buridan's paradigm. METHODOLOGY/PRINCIPAL
findingsWe present here a package of open source software designed to track a single animal walking in a homogenous environment (Buritrack) and to analyze its trajectory. The Centroid Trajectory Analysis (CeTrAn) software is coded in the open source statistics project R. It extracts eleven metrics and includes correlation analyses and a Principal Components Analysis (PCA). It was designed to be easily customized to personal requirements. In combination with inexpensive hardware, these tools can readily be used for teaching and research purposes. We demonstrate the capabilities of our package by measuring the locomotor behavior of adult Drosophila melanogaster (whose wings were clipped), either in the presence or in the absence of visual targets, and comparing the latter to different computer-generated data. The analysis of the trajectories confirms that flies are centrophobic and shows that inaccessible visual targets can alter the orientation of the flies without changing their overall patterns of activity. CONCLUSIONS/SIGNIFICANCE: Using computer generated data, the analysis software was tested, and chance values for some metrics (as well as chance value for their correlation) were set. Our results prompt the hypothesis that fixation behavior is observed only if negative phototaxis can overcome the propensity of the flies to avoid the center of the platform. Together with our companion paper, we provide new tools to promote Open Science as well as the collection and analysis of digital behavioral data.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.