ArticleFrontiers in molecular neuroscience2012
DSCAMs: restoring balance to developmental forces.
Article in Frontiers in molecular neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Future Directions for Studying the Potential of Mammalian Dscam in Autism Spectrum Disorder and Alzheimer's Disease: Insights from Dose Sensitivity.Molecular neurobiology · 2025Review
- Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation.Nature communications · 2024Article
- Synaptic cell adhesion molecules contribute to the pathogenesis and progression of fragile X syndrome.Frontiers in cellular neuroscience · 2024Review
- Integrated analysis of plasma proteome and cortex single-cell transcriptome reveals the novel biomarkers during cortical aging.Frontiers in aging neuroscience · 2023Article
- Deficiency in the cell-adhesion moleculeFrontiers in cell and developmental biology · 2023Article
- Role of DSCAM in the Development of Neural Control of Movement and Locomotion.International journal of molecular sciences · 2021Review
- Local Translation Across Neural Development: A Focus on Radial Glial Cells, Axons, and Synaptogenesis.Frontiers in molecular neuroscience · 2021Review
- DSCAM regulates delamination of neurons in the developing midbrain.Science advances · 2020Article
- ZebrafishThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- DSCAM promotes self-avoidance in the developing mouse retina by masking the functions of cadherin superfamily members.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Survey of Human Chromosome 21 Gene Expression Effects on Early Development inG3 (Bethesda, Md.) · 2018Article
- Transcriptome profiling reveals infection strategy of an insect maculavirus.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
- Regulation of neural circuit formation by protocadherins.Cellular and molecular life sciences : CMLS · 2017Review
- Homophilic Protocadherin Cell-Cell Interactions Promote Dendrite Complexity.Cell reports · 2016Article
- Design principles and developmental mechanisms underlying retinal mosaics.Biological reviews of the Cambridge Philosophical Society · 2015Review
- Protocadherins branch out: Multiple roles in dendrite development.Cell adhesion & migration · 2015Review
- DSCAM localization and function at the mouse cone synapse.The Journal of comparative neurology · 2014Article
- Genome-wide association and systems genetic analyses of residual feed intake, daily feed consumption, backfat and weight gain in pigs.BMC genetics · 2014Article
- Variants in DPF3 and DSCAML1 are associated with sperm morphology.Journal of assisted reproduction and genetics · 2014Article
- Introduction to mechanisms of neural circuit formation.Frontiers in molecular neuroscience · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Many of the models of neurodevelopmental processes such as cell migration, axon outgrowth, and dendrite arborization involve cell adhesion and chemoattraction as critical physical or mechanical aspects of the mechanism. However, the prevention of adhesion or attraction is under-appreciated as a necessary, active process that balances these forces, insuring that the correct cells are present and adhering in the correct place at the correct time. The phenomenon of not adhering is often viewed as the passive alternative to adhesion, and in some cases this may be true. However, it is becoming increasingly clear that active signaling pathways are involved in preventing adhesion. These provide a balancing force during development that prevents overly exuberant adhesion, which would otherwise disrupt normal cellular and tissue morphogenesis. The strength of chemoattractive signals may be similarly modulated. Recent studies, described here, suggest that Down Syndrome Cell Adhesion Molecule (DSCAM), and closely related proteins such as DSCAML1, may play an important developmental role as such balancers in multiple systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.