ArticlePLoS genetics2012
HAL-2 promotes homologous pairing during Caenorhabditis elegans meiosis by antagonizing inhibitory effects of synaptonemal complex precursors.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 46 citations in OpenAlex.
- Programmed DNA elimination was present in the last common ancestor ofbioRxiv : the preprint server for biology · 2026Article
- Forceful Beginnings: Mechanotransduction and Mechanosensation at the Meiotic Cell Nucleus During Gamete Development.Results and problems in cell differentiation · 2026Review
- Identification of the Polo-like kinase substrate required for homologous synapsis.The Journal of cell biology · 2025Article
- Article
- Review
- Recruitment of Polo-like kinase couples synapsis to meiotic progression via inactivation of CHK-2.eLife · 2023Article
- Targeting Polo-like kinase in space and time during C. elegans meiosis.Cell cycle (Georgetown, Tex.) · 2021Review
- Automated and customizable quantitative image analysis of whole Caenorhabditis elegans germlines.Genetics · 2021Article
- Synaptonemal Complex dimerization regulates chromosome alignment and crossover patterning in meiosis.PLoS genetics · 2021Article
- Spatial and temporal control of targeting Polo-like kinase during meiotic prophase.The Journal of cell biology · 2020Article
- Review
- Spatial Regulation of Polo-Like Kinase Activity DuringGenetics · 2019Article
- SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice.Nucleic acids research · 2019Article
- Condensin I protects meiotic cohesin from WAPL-1 mediated removal.PLoS genetics · 2018Article
- Zipping and Unzipping: Protein Modifications Regulating Synaptonemal Complex Dynamics.Trends in genetics : TIG · 2018Review
- Moving and stopping: Regulation of chromosome movement to promote meiotic chromosome pairing and synapsis.Nucleus (Austin, Tex.) · 2017Review
- Time-Course Analysis of Early Meiotic Prophase Events Informs Mechanisms of Homolog Pairing and Synapsis inGenetics · 2017Article
- Meiosis.WormBook : the online review of C. elegans biology · 2017Review
- Meiotic recombination modulates the structure and dynamics of the synaptonemal complex during C. elegans meiosis.PLoS genetics · 2017Article
- Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
During meiosis, chromosomes align with their homologous pairing partners and stabilize this alignment through assembly of the synaptonemal complex (SC). Since the SC assembles cooperatively yet is indifferent to homology, pairing and SC assembly must be tightly coordinated. We identify HAL-2 as a key mediator in this coordination, showing that HAL-2 promotes pairing largely by preventing detrimental effects of SC precursors (SYP proteins). hal-2 mutants fail to establish pairing and lack multiple markers of chromosome movement mediated by pairing centers (PCs), chromosome sites that link chromosomes to cytoplasmic microtubules through nuclear envelope-spanning complexes. Moreover, SYP proteins load inappropriately along individual unpaired chromosomes in hal-2 mutants, and markers of PC-dependent movement and function are restored in hal-2; syp double mutants. These and other data indicate that SYP proteins can impede pairing and that HAL-2 promotes pairing predominantly but not exclusively by counteracting this inhibition, thereby enabling activation and regulation of PC function. HAL-2 concentrates in the germ cell nucleoplasm and colocalizes with SYP proteins in nuclear aggregates when SC assembly is prevented. We propose that HAL-2 functions to shepherd SYP proteins prior to licensing of SC assembly, preventing untimely interactions between SC precursors and chromosomes and allowing sufficient accumulation of precursors for rapid cooperative assembly upon homology verification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.