ArticlePLoS genetics2012
Uncovering the genome-wide transcriptional responses of the filamentous fungus Aspergillus niger to lignocellulose using RNA sequencing.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
76 citing papers in PubMed, 156 citations in OpenAlex.
- Research Advances on the Functions of Transcriptional Regulators in Filamentous Fungi.Microorganisms · 2026Review
- Total fungal RNA extraction from complex solid- state fermentation products.Applied microbiology and biotechnology · 2026Article
- Three hydrophobic surface binding a proteins link surface hydrophobicity to sporulation, biofilm formation, and host interaction inFrontiers in cellular and infection microbiology · 2026Article
- Optimizing Scaled up Production and Purification of Recombinant Hydrophobin HFBI inMicroorganisms · 2025Article
- Morphogenesis, starvation, and light responses in a mushroom-forming fungus revealed by long-read sequencing and extensive expression profiling.Cell genomics · 2025Article
- Involvement of the intracellular β-glucosidase BGL1B from Aspergillus niger in the regulation of lignocellulose-degrading enzymes' synthesis.Biotechnology for biofuels and bioproducts · 2025Article
- A Multiomics Perspective on Plant Cell Wall-Degrading Enzyme Production: Insights from the Unexploited FungusJournal of fungi (Basel, Switzerland) · 2024Article
- The antifungal peptide AnAFP fromFrontiers in microbiology · 2024Article
- Enzyme activity of Aspergillus section Nigri strains isolated from the Korean fermentation starter, nuruk.Journal of microbiology (Seoul, Korea) · 2022Article
- Review
- Strategies Shaping the Transcription of Carbohydrate-Active Enzyme Genes inJournal of fungi (Basel, Switzerland) · 2022Article
- Assessing the intracellular primary metabolic profile ofFrontiers in fungal biology · 2022Article
- Xylo-Oligosaccharide Utilization by EngineeredFrontiers in bioengineering and biotechnology · 2022Review
- Evidence for Lignocellulose-Decomposing Enzymes in the Genome and Transcriptome of the Aquatic HyphomyceteJournal of fungi (Basel, Switzerland) · 2021Article
- The F-box protein geneProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Detection of glucosamine as a marker for Aspergillus niger: a potential screening method for fungal infections.Analytical and bioanalytical chemistry · 2021Article
- Comparative transcriptional analyses of Pleurotus ostreatus mutants on beech wood and rice straw shed light on substrate-biased gene regulation.Applied microbiology and biotechnology · 2021Article
- Genetic Characterization of Mutations Related to Conidiophore Stalk Length Development inFrontiers in genetics · 2021Article
- Succession of physiological stages hallmarks the transcriptomic response of the fungusBiotechnology for biofuels · 2020Article
- Identification and Characterization of a Cellodextrin Transporter inFrontiers in microbiology · 2020Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
A key challenge in the production of second generation biofuels is the conversion of lignocellulosic substrates into fermentable sugars. Enzymes, particularly those from fungi, are a central part of this process, and many have been isolated and characterised. However, relatively little is known of how fungi respond to lignocellulose and produce the enzymes necessary for dis-assembly of plant biomass. We studied the physiological response of the fungus Aspergillus niger when exposed to wheat straw as a model lignocellulosic substrate. Using RNA sequencing we showed that, 24 hours after exposure to straw, gene expression of known and presumptive plant cell wall-degrading enzymes represents a huge investment for the cells (about 20% of the total mRNA). Our results also uncovered new esterases and surface interacting proteins that might form part of the fungal arsenal of enzymes for the degradation of plant biomass. Using transcription factor deletion mutants (xlnR and creA) to study the response to both lignocellulosic substrates and low carbon source concentrations, we showed that a subset of genes coding for degradative enzymes is induced by starvation. Our data support a model whereby this subset of enzymes plays a scouting role under starvation conditions, testing for available complex polysaccharides and liberating inducing sugars, that triggers the subsequent induction of the majority of hydrolases. We also showed that antisense transcripts are abundant and that their expression can be regulated by growth conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.