ArticlePLoS genetics2012
Drosophila Hox and sex-determination genes control segment elimination through EGFR and extramacrochetae activity.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- PBX-dependent and independent Hox programs establish and maintain motor neuron terminal Identity.bioRxiv : the preprint server for biology · 2025Article
- Ambivalent partnership of the Drosophila posterior class Hox protein Abdominal-B with Extradenticle and Homothorax.PLoS genetics · 2025Article
- High-quality chromosome-level genome assembly of femaleHeliyon · 2024Article
- Long Non-Coding RNAInsects · 2022Article
- Upgraded CRISPR/Cas9 tools for tissue-specific mutagenesis inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Hox geneDevelopment (Cambridge, England) · 2019Article
- Transgenerational response to early spring warming in Daphnia.Scientific reports · 2019Article
- MeDIP-seq and nCpG analyses illuminate sexually dimorphic methylation of gonadal development genes with high historic methylation in turtle hatchlings with temperature-dependent sex determination.Epigenetics & chromatin · 2017Article
- Double nexus--Doublesex is the connecting element in sex determination.Briefings in functional genomics · 2015Review
- Functional Requirements for Fab-7 Boundary Activity in the Bithorax Complex.Molecular and cellular biology · 2015Article
- Sex- and tissue-specific functions of Drosophila doublesex transcription factor target genes.Developmental cell · 2014Article
- Role of abd-A and Abd-B in development of abdominal epithelia breaks posterior prevalence rule.PLoS genetics · 2014Article
- Early embryonic determination of the sexual dimorphism in segment number in geophilomorph centipedes.EvoDevo · 2013Article
- Hox targets and cellular functions.Scientifica · 2013Article
- Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
Abstract
The formation or suppression of particular structures is a major change occurring in development and evolution. One example of such change is the absence of the seventh abdominal segment (A7) in Drosophila males. We show here that there is a down-regulation of EGFR activity and fewer histoblasts in the male A7 in early pupae. If this activity is elevated, cell number increases and a small segment develops in the adult. At later pupal stages, the remaining precursors of the A7 are extruded under the epithelium. This extrusion requires the up-regulation of the HLH protein Extramacrochetae and correlates with high levels of spaghetti-squash, the gene encoding the regulatory light chain of the non-muscle myosin II. The Hox gene Abdominal-B controls both the down-regulation of spitz, a ligand of the EGFR pathway, and the up-regulation of extramacrochetae, and also regulates the transcription of the sex-determining gene doublesex. The male Doublesex protein, in turn, controls extramacrochetae and spaghetti-squash expression. In females, the EGFR pathway is also down-regulated in the A7 but extramacrochetae and spaghetti-squash are not up-regulated and extrusion of precursor cells is almost absent. Our results show the complex orchestration of cellular and genetic events that lead to this important sexually dimorphic character change.
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Registered trials
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