Evidence map›Paper›PMID 22912545›Full record

ReviewWorld journal of gastroenterology2012

Overview and developments in noninvasive diagnosis of nonalcoholic fatty liver disease.

Neven Baršić, Ivan Lerotić, Lea Smirčić-Duvnjak, Vedran Tomašić, Marko Duvnjak

Abstract readReview
In one paragraph

Review in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Observational
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Noninvasive Evaluation of Liver Function in Morbidly Obese Patients.Gastroenterology research and practice · 2019
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Non-alcoholic fatty liver disease in 2016.British medical bulletin · 2016
    Review
  18. Observational
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Neven BaršićDivision of Gastroenterology and Hepatology, Department of Medicine, "Sestre milosrdnice" University Hospital Center, 10000 Zagreb, Croatia.
Ivan Lerotić
Lea Smirčić-Duvnjak
Vedran Tomašić
Marko Duvnjak

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High prevalence of non-alcoholic fatty liver disease (NAFLD) and very diverse outcomes that are related to disease form and severity at presentation have made the search for noninvasive diagnostic tools in NAFLD one of the areas with most intense development in hepatology today. Various methods have been investigated in the recent years, including imaging methods like ultrasound and magnetic resonance imaging, different forms of liver stiffness measurement, various biomarkers of necroinflammatory processes (acute phase reactants, cytokines, markers of apoptosis), hyaluronic acid and other biomarkers of liver fibrosis. Multicomponent tests, scoring systems and diagnostic panels were also developed with the purposes of differentiating non-alcoholic steatohepatitis from simple steatosis or discriminating between various fibrosis stages. In all of the cases, performance of noninvasive methods was compared with liver biopsy, which is still considered to be a gold standard in diagnosis, but is by itself far from a perfect comparative measure. We present here the overview of the published data on various noninvasive diagnostic tools, some of which appear to be very promising, and we address as well some of still unresolved issues in this interesting field.

Indexed as

AdiponectinBiomarkersChemokine CCL2C-Reactive ProteinElasticity Imaging TechniquesFatty LiverHumansHyaluronic AcidInsulin ResistanceInterleukin-6Keratin-18Liver CirrhosisLiver Function TestsMagnetic Resonance ImagingNon-alcoholic Fatty Liver DiseaseTomography, X-Ray ComputedAdiponectinBiomarkersCCL2 protein, humanChemokine CCL2C-Reactive ProteinHyaluronic AcidInterleukin-6Keratin-18Tumor Necrosis Factor-alphaBiomarkersCytokeratin-18Hyaluronic acidInsulin resistanceLiver biopsyLiver fibrosisNon-alcoholic fatty liver diseaseNon-alcoholic steatohepatitisOxidative stressTransient elastography

Identifiers

PMID22912545
PMCPMC3419991

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.