ArticleDevelopment (Cambridge, England)2012
Principles of branch dynamics governing shape characteristics of cerebellar Purkinje cell dendrites.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Mesenchymal and neural stem cell differentiation into Purkinje-like cells: Morphological study.Journal of Taibah University Medical Sciences · 2026Article
- PKCγ-mediated Phosphorylation of Mtss1 Regulates the Dendritic Outgrowth and Spine Development of Cerebellar Purkinje Cells.Molecular neurobiology · 2025Article
- Neuronal branching in stem cell models of mitochondrial and neurological diseases.Stem cells (Dayton, Ohio) · 2025Review
- Neurodevelopmental origins of structural and psychomotor defects in CXCR4-linked primary immunodeficiency.Neuron · 2025Article
- Neurons exploit stochastic growth to rapidly and economically build dense dendritic arbors.Nature communications · 2025Article
- Development and Optimization of a Multilayer Rat Purkinje Neuron Culture.Cerebellum (London, England) · 2024Article
- Topology recapitulates morphogenesis of neuronal dendrites.Cell reports · 2023Article
- Article
- Models of Purkinje cell dendritic tree selection during early cerebellar development.PLoS computational biology · 2023Article
- Dendritic Morphology Affects the Velocity and Amplitude of Back-propagating Action Potentials.Neuroscience bulletin · 2022Article
- Establishment and characterization of human pluripotent stem cells-derived brain organoids to model cerebellar diseases.Scientific reports · 2022Article
- Mathematical models of neuronal growth.Biomechanics and modeling in mechanobiology · 2022Review
- Theory of branching morphogenesis by local interactions and global guidance.Nature communications · 2021Article
- The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner.Cell reports · 2021Article
- Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates.Acta neuropathologica communications · 2021Article
- Soy Isoflavones Accelerate Glial Cell MigrationFrontiers in endocrinology · 2020Article
- Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice.Molecular brain · 2019Article
- Dendritic Self-Avoidance and Morphological Development of Cerebellar Purkinje Cells.Cerebellum (London, England) · 2018Review
- Statistical theory of branching morphogenesis.Development, growth & differentiation · 2018Review
- Differential dynamics of cortical neuron dendritic trees revealed by long-term in vivo imaging in neonates.Nature communications · 2018Article
Corrections and comments
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons develop dendritic arbors in cell type-specific patterns. Using growing Purkinje cells in culture as a model, we performed a long-term time-lapse observation of dendrite branch dynamics to understand the rules that govern the characteristic space-filling dendrites. We found that dendrite architecture was sculpted by a combination of reproducible dynamic processes, including constant tip elongation, stochastic terminal branching, and retraction triggered by contacts between growing dendrites. Inhibition of protein kinase C/protein kinase D signaling prevented branch retraction and significantly altered the characteristic morphology of long proximal segments. A computer simulation of dendrite branch dynamics using simple parameters from experimental measurements reproduced the time-dependent changes in the dendrite configuration in live Purkinje cells. Furthermore, perturbation analysis to parameters in silico validated the important contribution of dendritic retraction in the formation of the characteristic morphology. We present an approach using live imaging and computer simulations to clarify the fundamental mechanisms of dendrite patterning in the developing brain.
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