ArticleDevelopment (Cambridge, England)2012
Germline potential of parthenogenetic haploid mouse embryonic stem cells.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed.
- Mitochondrial metabolic imbalance drives diploidization in mouse haploid embryonic stem cells via NADPH overload.Nature communications · 2026Article
- Characterizing Marine Medaka (Animals : an open access journal from MDPI · 2024Article
- Genetic Screening of Haploid Neural Stem Cells Reveals that Nfkbia and Atp2b4 are Key Regulators of Oxidative Stress in Neural Precursors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3.Nature communications · 2021Article
- High-throughput screening in postimplantation haploid epiblast stem cells reveals Hs3st3b1 as a modulator for reprogramming.Stem cells translational medicine · 2021Article
- A preview of selected articles.Stem cells translational medicine · 2021Article
- Cooperative genetic networks drive embryonic stem cell transition from naïve to formative pluripotency.The EMBO journal · 2021Article
- Inhibition of Apoptosis Reduces Diploidization of Haploid Mouse Embryonic Stem Cells during Differentiation.Stem cell reports · 2020Article
- Reproduction reimagined.F&S reports · 2020Article
- Current advances in haploid stem cells.Protein & cell · 2020Review
- The milestone of genetic screening: Mammalian haploid cells.Computational and structural biotechnology journal · 2020Review
- Controlled ploidy reduction of pluripotent 4n cells generates 2n cells during mouse embryo development.Science advances · 2019Article
- Derivation and maintenance of mouse haploid embryonic stem cells.Nature protocols · 2019Article
- Mammalian haploid stem cells: establishment, engineering and applications.Cellular and molecular life sciences : CMLS · 2019Review
- Defined conditions for propagation and manipulation of mouse embryonic stem cells.Development (Cambridge, England) · 2019Article
- Haploid embryonic stem cells can be enriched and maintained by simple filtration.The Journal of biological chemistry · 2018Article
- Reduced Self-Diploidization and Improved Survival of Semi-cloned Mice Produced from Androgenetic Haploid Embryonic Stem Cells through Overexpression of Dnmt3b.Stem cell reports · 2018Article
- Novel imprinted single CpG sites found by global DNA methylation analysis in human parthenogenetic induced pluripotent stem cells.Epigenetics · 2018Article
- Arrayed mutant haploid embryonic stem cell libraries facilitate phenotype-driven genetic screens.Nucleic acids research · 2017Article
- Stabilization of mouse haploid embryonic stem cells with combined kinase and signal modulation.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Haploid embryonic stem cells (ESCs) have recently been derived from parthenogenetic mouse embryos and offer new possibilities for genetic screens. The ability of haploid ESCs to give rise to a wide range of differentiated cell types in the embryo and in vitro has been demonstrated. However, it has remained unclear whether haploid ESCs can contribute to the germline. Here, we show that parthenogenetic haploid ESCs at high passage have robust germline competence enabling the production of transgenic mouse strains from genetically modified haploid ESCs. We also show that differentiation of haploid ESCs in the embryo correlates with the gain of a diploid karyotype and that diploidisation is the result of endoreduplication and not cell fusion. By contrast, we find that a haploid karyotype is maintained when differentiation to an extra-embryonic fate is forced by induction of Gata6.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.