Evidence map›Paper›PMID 22912410›Full record

ReviewDevelopment (Cambridge, England)2012

Principles and roles of mRNA localization in animal development.

Caroline Medioni, Kimberly Mowry, Florence Besse

Abstract readReview
In one paragraph

Review in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 232 citations in OpenAlex.

  1. Subcellularly Resolved 3D Translatome in Mouse Oocytes and Early Embryos.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Cracking the (zip)code of dynein-dependent RNA localization.Nature structural & molecular biology · 2026
    Article
  7. Bioluminescent Probes for Multiplexed RNA Imaging.Journal of the American Chemical Society · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. PTBP1 and Cancer: From RNA Regulation to Therapeutic Potential.Journal of cellular and molecular medicine · 2025
    Review
  16. Article
  17. Landscape and regulation of mRNA translation in the earlybioRxiv : the preprint server for biology · 2025
    Article
  18. Article
  19. Article
  20. Article

70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Caroline MedioniInstitute of Biology Valrose, University of Nice-Sophia Antipolis/UMR7277 CNRS/UMR1091 INSERM, Parc Valrose, 06108 Nice Cedex 2, France.
Kimberly Mowry
Florence Besse
Centre National de la Recherche Scientifique · FRBrown University · US

Funding

RNA Localization in Xenopus OocytesR01GM071049 · NIGMS · BROWN UNIVERSITY · PI MOWRY, KIMBERLY L. · 2005 to 2018
$4.2M
NIGMS NIH HHS GM071049NIGMS NIH HHS R01 GM071049
6 · The paper itself

Abstract

Intracellular targeting of mRNAs has long been recognized as a means to produce proteins locally, but has only recently emerged as a prevalent mechanism used by a wide variety of polarized cell types. Localization of mRNA molecules within the cytoplasm provides a basis for cell polarization, thus underlying developmental processes such as asymmetric cell division, cell migration, neuronal maturation and embryonic patterning. In this review, we describe and discuss recent advances in our understanding of both the regulation and functions of RNA localization during animal development.

Indexed as

AnimalsAsymmetric Cell DivisionBody PatterningCell PolarityCytoplasmRNA, MessengerRNA, Messenger

Identifiers

PMID22912410
PMCPMC3424039
OpenAlexW1985316936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.