ArticleAmerican journal of clinical pathology2012
Clinicopathologic and genetic characterization of traditional serrated adenomas of the colon.
Article in American journal of clinical pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
- Rate of detection of serrated lesions at colonoscopy in an average-risk population: a meta-analysis of 129,001 individuals.Endoscopy international open · 2021Article
- Correlations of morphology and molecular alterations in traditional serrated adenoma.World journal of gastrointestinal pathophysiology · 2020Review
- An update on the morphology and molecular pathology of serrated colorectal polyps and associated carcinomas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Review
- Traditional serrated adenoma: an overview of pathology and emphasis on molecular pathogenesis.BMJ open gastroenterology · 2019Review
- Colorectal Serrated Neoplasia: An Institutional 12-Year Review Highlights the Impact of a Screening Programme.Gastroenterology research and practice · 2019Article
- The Serrated Polyp Pathway: Is It Time to Alter Surveillance Guidelines?Current gastroenterology reports · 2017Review
- Colorectal Cancer Screening: A Comprehensive Review to Recent Non-Invasive Methods.International journal of hematology-oncology and stem cell research · 2017Review
- TRIM37 promotes epithelial‑mesenchymal transition in colorectal cancer.Molecular medicine reports · 2017Article
- The clinical impact of serrated colorectal polyps.Clinical epidemiology · 2017Review
- Molecular characteristics of colorectal serrated polyps and hyperplastic polyps: A STROBE compliant article.Medicine · 2016Observational
- Serrated Polyps and Serrated Polyposis Syndrome.Clinics in colon and rectal surgery · 2016Review
- Inflammatory response in serrated precursor lesions of the colon classified according to WHO entities, clinical parameters and phenotype-genotype correlation.The journal of pathology. Clinical research · 2016Article
- Molecular pathogenesis of sporadic colorectal cancers.Chinese journal of cancer · 2016Review
- A clinicopathological and molecular analysis of 200 traditional serrated adenomas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015Article
- Risk factors for serrated polyps of the colorectum.Digestive diseases and sciences · 2014Review
- The significance of ectopic crypt formation in the differential diagnosis of colorectal polyps.Diagnostic pathology · 2014Article
- IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions.World journal of gastroenterology · 2014Article
- Reappraisal of the so-called 'villous tumours' of the rectosigmoid, based on histological, immunohistochemical and genotypic features.United European gastroenterology journal · 2014Article
- Long interspersed element-1 protein expression is a hallmark of many human cancers.The American journal of pathology · 2014Article
- Serrated neoplasia of the colon: what do we really know?Current gastroenterology reports · 2014Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
Traditional serrated adenomas (TSAs) are a type of colorectal polyp with neoplastic potential. Immunohistochemical analysis and sequencing were performed on 24 TSAs from 23 patients to characterize the molecular genetics of TSAs. Abnormal Ki-67 and p53 labeling were observed in 7 (29%) of 24 and 6 (25%) of 24 TSAs, respectively; both types were significantly associated with the presence of conventional epithelial dysplasia (P = .0005 and P = .0001, respectively). Activating KRAS mutation was identified in 11 TSAs (46%) and was mutually exclusive with activating BRAF mutations, which were seen in 7 TSAs (29%). Abnormal p53 nuclear labeling in a TSA was significantly associated with BRAF mutation status (P = .04), whereas no relationship was found for β-catenin labeling patterns. The overall morphologic features of TSA do not correlate with the genetic status of the KRAS and BRAF genes. However, conventional epithelial dysplasia and abnormal p53 labeling in a TSA are seen more often in the setting of BRAF mutation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.