ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2012
Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- DNA methylation and general psychopathology in childhood: an epigenome-wide meta-analysis from the PACE consortium.Molecular psychiatry · 2023Pooled it
- Shared and distinct genetic architectures of eating disorders and obesity: From monogenic causes to polygenic risk.Reviews in endocrine & metabolic disorders · 2026Review
- Association ofJournal of clinical medicine · 2024Article
- Meal timing and its role in obesity and associated diseases.Frontiers in endocrinology · 2024Review
- Genetic variants in genes involved in creatine biosynthesis in patients with severe obesity or anorexia nervosa.Frontiers in genetics · 2023Article
- Eating disorder symptoms and their associations with anthropometric and psychiatric polygenic scores.European eating disorders review : the journal of the Eating Disorders Association · 2022Article
- Variability in cannabinoid receptor genes is associated with psychiatric comorbidities in anorexia nervosa.Eating and weight disorders : EWD · 2021Article
- Genetic variants in dopamine pathways affect personality dimensions displayed by patients with eating disorders.Eating and weight disorders : EWD · 2021Article
- Longitudinal associations between circulating interleukin-6 and C-reactive protein in childhood, and eating disorders and disordered eating in adolescence.Brain, behavior, and immunity · 2020Review
- Genome-wide association study of breakfast skipping links clock regulation with food timing.The American journal of clinical nutrition · 2019Article
- Timing of Food Intake: Identifying Contributing Factors to Design Effective Interventions.Advances in nutrition (Bethesda, Md.) · 2019Review
- Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank.Translational psychiatry · 2017Article
- Modeling anorexia nervosa: transcriptional insights from human iPSC-derived neurons.Translational psychiatry · 2017Article
- Genome-wide association study of body mass index in subjects with alcohol dependence.Addiction biology · 2017Article
- A Primer on the Genetics of Comorbid Eating Disorders and Substance Use Disorders.European eating disorders review : the journal of the Eating Disorders Association · 2016Review
- Behavioral and neurodevelopmental precursors to binge-type eating disorders: support for the role of negative valence systems.Psychological medicine · 2015Review
- Genetic variants in AKR1B10 associate with human eating behavior.BMC genetics · 2015Article
- A genome-wide association study of anorexia nervosa.Molecular psychiatry · 2014Article
- Genetics of eating disorders.Current psychiatry reports · 2013Review
- Genetic variants associated with disordered eating.The International journal of eating disorders · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
Abstract
Eating disorders (EDs) are common, complex psychiatric disorders thought to be caused by both genetic and environmental factors. They share many symptoms, behaviors, and personality traits, which may have overlapping heritability. The aim of the present study is to perform a genome-wide association scan (GWAS) of six ED phenotypes comprising three symptom traits from the Eating Disorders Inventory 2 [Drive for Thinness (DT), Body Dissatisfaction (BD), and Bulimia], Weight Fluctuation symptom, Breakfast Skipping behavior and Childhood Obsessive-Compulsive Personality Disorder trait (CHIRP). Investigated traits were derived from standardized self-report questionnaires completed by the TwinsUK population-based cohort. We tested 283,744 directly typed SNPs across six phenotypes of interest in the TwinsUK discovery dataset and followed-up signals from various strata using a two-stage replication strategy in two independent cohorts of European ancestry. We meta-analyzed a total of 2,698 individuals for DT, 2,680 for BD, 2,789 (821 cases/1,968 controls) for Bulimia, 1,360 (633 cases/727 controls) for Childhood Obsessive-Compulsive Personality Disorder trait, 2,773 (761 cases/2,012 controls) for Breakfast Skipping, and 2,967 (798 cases/2,169 controls) for Weight Fluctuation symptom. In this GWAS analysis of six ED-related phenotypes, we detected association of eight genetic variants with P < 10(-5) . Genetic variants that showed suggestive evidence of association were previously associated with several psychiatric disorders and ED-related phenotypes. Our study indicates that larger-scale collaborative studies will be needed to achieve the necessary power to detect loci underlying ED-related traits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.