ArticlePloS one2012
H1-MAPT and the risk for familial essential tremor.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The microtubule associated protein tau H1 haplotype and risk of essential tremor.European journal of neurology · 2014Pooled it
- Vitamin D Receptor and Binding Protein Gene Variants in Patients with Essential Tremor.Molecular neurobiology · 2022Article
- Tau Isoform Profile in Essential Tremor Diverges From Other Tauopathies.Journal of neuropathology and experimental neurology · 2021Article
- Genomic Markers for Essential Tremor.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Genetic Risk Factors for Essential Tremor: A Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Review
- Essential tremor.Handbook of clinical neurology · 2018Review
- Cerebellar Pathology in Familial vs. Sporadic Essential Tremor.Cerebellum (London, England) · 2017Article
- Statin Use and Its Association with Essential Tremor and Parkinson's Disease.Neuroepidemiology · 2016Article
- MAPT1 gene rs1052553 variant is unrelated with the risk for restless legs syndrome.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- Specific profile of tau isoforms in argyrophylic grain disease.Journal of experimental neuroscience · 2013Article
- Challenges in essential tremor genetics.Revue neurologiqueReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most frequent MAPT H1 haplotype is associated with the risk for developing progressive supranuclear palsy and other neurodegenerative diseases such as Parkinson's disease. A recent report suggests that the MAPT H1 is associated with the risk for developing essential tremor. We wanted to confirm this association in a different population. We analyzed the distribution of allelic and genotype frequencies of rs1052553, which is an H1/H2 SNP, in 200 subjects with familial ET and 291 healthy controls. rs1052553 genotype and allelic frequencies did not differ significantly between subjects with ET and controls and were unrelated with the age at onset of tremor or gender, and with the presence of head, voice, chin, and tongue tremor. Our study suggests that the MAPT H1 rs1052553 is not associated with the risk for developing familial ET in the Spanish population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.