ArticleJournal of gastroenterology2013
Accumulation of platelets in the liver may be an important contributory factor to thrombocytopenia and liver fibrosis in chronic hepatitis C.
Article in Journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Assessment of Prognostic Value of Aspartate Aminotransferase-to-Platelet Ratio Index in Patients With Hepatocellular Carcinoma: Meta-Analysis of 28 Cohort Studies.Frontiers in medicine · 2021Pooled it
- The Prognostic Value of Platelet Count in Patients With Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.Medicine · 2015Pooled it
- Thrombocytopenia for prediction of hepatocellular carcinoma recurrence: Systematic review and meta-analysis.World journal of gastroenterology · 2015Pooled it
- Intrahepatic Platelets Orchestrate Microenvironmental Remodelling and Cellular Crosstalk in Liver Fibrosis.Liver international : official journal of the International Association for the Study of the Liver · 2026Review
- Survival analysis of patients with hepatocellular carcinoma based on the ratio of platelet count to spleen diameter.Frontiers in pharmacology · 2024Article
- Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy.Journal of hepatology · 2021Article
- Pathological characteristics of liver sinusoidal thrombosis in COVID-19 patients: A series of 43 cases.Hepatology research : the official journal of the Japan Society of Hepatology · 2021Article
- Recurrence Beyond the Milan Criteria of HBV-Related Single Hepatocellular Carcinoma of 2-3 cm: Comparison of Resection and Ablation.Frontiers in oncology · 2021Article
- Effect of Direct-Acting Antiviral Therapy on Thrombocytopenic Patients with Hepatitis C Virus-Related Chronic Liver Disease.Gastroenterology research and practice · 2021Article
- Relationship between platelet-based models and the prognosis of patients with malignant hepatic tumors.Oncology letters · 2020Article
- Exploring the Link Between Platelet Numbers and Vascular Homeostasis Across Early and Late Stages of Fibrosis in Hepatitis C.Digestive diseases and sciences · 2020Article
- Hepatocellular Carcinoma Within the Milan Criteria: A Novel Inflammation-Based Nomogram System to Assess the Outcomes of Ablation.Frontiers in oncology · 2020Article
- The diagnostic nomogram of platelet-based score models for hepatic alveolar echinococcosis and atypical liver cancer.Scientific reports · 2019Article
- Platelets in chronic liver disease, from bench to bedside.JHEP reports : innovation in hepatology · 2019Review
- Comparison of the prognostic value of platelet-based prognostic models in patients with malignant hepatic tumors after TACE therapy.Acta cirurgica brasileira · 2019Article
- Platelets as Key Factors in Hepatocellular Carcinoma.Cancers · 2019Review
- Measuring and interpreting platelet-leukocyte aggregates.Platelets · 2018Review
- Platelets as Modulators of Liver Diseases.Seminars in thrombosis and hemostasis · 2018Review
- Nonsteroidal anti-inflammatory drugs, especially aspirin, are linked to lower risk and better survival of hepatocellular carcinoma: a meta-analysis.Cancer management and research · 2018Article
- Can platelet indices be used as predictors of complication in subjects with appendicitis?Wiener klinische Wochenschrift · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThrombocytopenia is a marked feature of chronic liver disease and cirrhosis. We tried to clarify whether an accumulation of platelets in the liver contributes to thrombocytopenia and liver fibrosis in chronic liver disease.
methodsThirty-eight patients who underwent hepatectomy for hepatocellular carcinoma (HCC) with hepatitis C virus infection were included. The locations of platelets and Kupffer cells and the expression of platelet-derived growth factor (PDGF) receptor-β and smooth muscle actin (SMA) were identified by immunohistochemistry. Perisinusoidal mesenchymal cells that express PDGF receptor-β and SMA were interpreted as transformed hepatic stellate cells (HSCs).
resultsPatients with cirrhosis had a more extensive platelet area in the liver compared to controls (5601 ± 5611 vs. 564 ± 361 μm(2), p = 0.02), although the blood platelet count significantly decreased along with the progression of liver fibrosis. In cirrhotic liver, most platelets were present in the sinusoidal space of the periportal area with inflammation, where HSCs expressing PDGF receptor-β were frequently observed. In addition, the platelet and Kupffer cell areas were significantly smaller in cancerous tissue than those in noncancerous tissues (platelet area: 492 ± 823 vs. 3643 ± 4055 μm(2), p = 0.001; Kupffer cell area: 450 ± 841 vs. 3012 ± 3051 μm(2), p = 0.001).
conclusionsThe accumulation of platelets in the liver with chronic hepatitis may be involved in thrombocytopenia and liver fibrosis through the activation of HSCs. In addition, our findings also indicate that both platelets and Kupffer cells decrease in HCC tissues.
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