ArticlePLoS biology2012
The vestibular system implements a linear-nonlinear transformation in order to encode self-motion.
Article in PLoS biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Dependency of human neck reflex responses on the bandwidth of pseudorandom anterior-posterior torso perturbations.Experimental brain research · 2013Trial
- Distributed burst firing mediates optimized cortical encoding of natural self-motion.Science advances · 2026Article
- Ground-truth encoding of self-motion in the primate cerebellar nodulus and uvula.Nature communications · 2026Article
- Head kinematic variability is minimal near preferred cadence and independent of the vestibular control of locomotion.Scientific reports · 2025Article
- Balance control threshold to vestibular stimuli.The Journal of physiology · 2025Article
- Convergence of vestibular and proprioceptive signals in the cerebellar nodulus/uvula enhances the encoding of self-motion in primates.Current biology : CB · 2025Article
- Angular Head Velocity Cells within Brainstem Nuclei Projecting to the Head Direction Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Vestibular Contributions to Primate Neck Postural Muscle Activity during Natural Motion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Advanced Bioelectrical Signal Processing Methods: Past, Present, and Future Approach-Part III: Other Biosignals.Sensors (Basel, Switzerland) · 2021Review
- Loss of peripheral vestibular input alters the statistics of head movement experienced during natural self-motion.The Journal of physiology · 2021Article
- Effects of perceptible and imperceptible galvanic vestibular stimulation on the postural control of patients with bilateral vestibulopathy.Journal of neurology · 2020Article
- [Optimal design of neural modulation strategy of vestibular prosthesis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020Article
- Dominant parameter of galvanic vestibular stimulation for the non-associative learning processes.Medical & biological engineering & computing · 2020Article
- Rapid Estrogenic and Androgenic Neurosteroids Effects in the Induction of Long-Term Synaptic Changes: Implication for Early Memory Formation.Frontiers in neuroscience · 2020Review
- Cerebellar Prediction of the Dynamic Sensory Consequences of Gravity.Current biology : CB · 2019Article
- Article
- Vestibular processing during natural self-motion: implications for perception and action.Nature reviews. Neuroscience · 2019Review
- Improvement of Mechanical Stability for Single Unit Recording Based on Skull Cap in Living Chinchilla.Current medical science · 2019Article
- Article
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Authors and funding
4 authors.
Funding
Abstract
Although it is well established that the neural code representing the world changes at each stage of a sensory pathway, the transformations that mediate these changes are not well understood. Here we show that self-motion (i.e. vestibular) sensory information encoded by VIIIth nerve afferents is integrated nonlinearly by post-synaptic central vestibular neurons. This response nonlinearity was characterized by a strong (~50%) attenuation in neuronal sensitivity to low frequency stimuli when presented concurrently with high frequency stimuli. Using computational methods, we further demonstrate that a static boosting nonlinearity in the input-output relationship of central vestibular neurons accounts for this unexpected result. Specifically, when low and high frequency stimuli are presented concurrently, this boosting nonlinearity causes an intensity-dependent bias in the output firing rate, thereby attenuating neuronal sensitivities. We suggest that nonlinear integration of afferent input extends the coding range of central vestibular neurons and enables them to better extract the high frequency features of self-motion when embedded with low frequency motion during natural movements. These findings challenge the traditional notion that the vestibular system uses a linear rate code to transmit information and have important consequences for understanding how the representation of sensory information changes across sensory pathways.
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Registered trials
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