ArticleBone2012
Comparison of bone tissue properties in mouse models with collagenous and non-collagenous genetic mutations using FTIRI.
Article in Bone, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Assessment of submicron bone tissue composition in plastic-embedded samples using optical photothermal infrared (O-PTIR) spectral imaging and machine learning.Journal of structural biology: X · 2024Article
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- Abnormal Bone Tissue Organization and Osteocyte Lacunocanalicular Network in Early-Onset Osteoporosis Due toJBMR plus · 2021Article
- Intrafibrillar mineralization deficiency and osteogenesis imperfecta mouse bone fragility.Journal of the mechanical behavior of biomedical materials · 2021Article
- Effects of teriparatide on bone in autochthonous transgenic model mice for diabetes mellitus (Akita mice).Osteoporosis and sarcopenia · 2019Article
- Impact of vitamin C on teriparatide treatment in the improvement of bone mineral density, strength, and quality in vitamin C-deficient rats.Journal of bone and mineral metabolism · 2019Article
- Role of SMPD3 during Bone Fracture Healing and Regulation of Its Expression.Molecular and cellular biology · 2019Article
- Bone quality changes associated with aging and disease: a review.Annals of the New York Academy of Sciences · 2017Review
- Correlations Between Bone Mechanical Properties and Bone Composition Parameters in Mouse Models of Dominant and Recessive Osteogenesis Imperfecta and the Response to Anti-TGF-β Treatment.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Decreasing maternal myostatin programs adult offspring bone strength in a mouse model of osteogenesis imperfecta.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Smpd3 Expression in both Chondrocytes and Osteoblasts Is Required for Normal Endochondral Bone Development.Molecular and cellular biology · 2016Article
- Bone mineral properties in growing Col1a2(+/G610C) mice, an animal model of osteogenesis imperfecta.Bone · 2016Article
- Myostatin deficiency partially rescues the bone phenotype of osteogenesis imperfecta model mice.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Are Changes in Composition in Response to Treatment of a Mouse Model of Osteogenesis Imperfecta Sex-dependent?Clinical orthopaedics and related research · 2015Article
- Sphingolipid metabolism and its role in the skeletal tissues.Cellular and molecular life sciences : CMLS · 2015Review
- Biomodification of PCL Scaffolds with Matrigel, HA, and SR1 Enhances De Novo Ectopic Bone Marrow Formation Induced by rhBMP-2.BioResearch open access · 2015Article
- How tough is brittle bone? Investigating osteogenesis imperfecta in mouse bone.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- A mouse model for human osteogenesis imperfecta type VI.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013Article
- Gender-dependence of bone structure and properties in adult osteogenesis imperfecta murine model.Annals of biomedical engineering · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Understanding how the material properties of bone tissue from the various forms of osteogenesis imperfecta (OI) differ will allow us to tailor treatment regimens for affected patients. To this end, we characterized the bone structure and material properties of two mouse models of OI, the osteogenesis imperfecta mouse (oim/oim) and fragilitas ossium (fro/fro), in which bone fragility is due to a genetic defect in collagen type I and a defect in osteoblast matrix mineralization, respectively. Bones from 3 to 6 month old animals were examined using Fourier transform infrared spectroscopic imaging (FTIRI), microcomputed tomography (micro-CT), histology, and biochemical analysis. The attributes of oim/oim bone tissue were relatively constant over time when compared to wild type animals. The mineral density in oim/oim cortices and trabecular bone was higher than wild type while the bones had thinner cortices and fewer trabeculae that were thinner and more widely spaced. The fro/fro animals exhibited osteopenic attributes at 3 months. However, by 6 months, their spectroscopic and geometric properties were similar to wild type animals. Despite the lack of a specific collagen defect in fro/fro mice, both fro/fro and oim/oim genotypes exhibited abnormal collagen crosslinking as determined by FTIRI at both time points. These results demonstrate that abnormal extracellular matrix assembly plays a role in the bone fragility in both of these models.
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