ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2012
Effect of genetic variant in BICC1 on functional and structural brain changes in depression.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Neuroimaging genomic studies in major depressive disorder: A systematic review.CNS neuroscience & therapeutics · 2018Pooled it
- Meta-analysis of associations between childhood adversity and hippocampus and amygdala volume in non-clinical and general population samples.NeuroImage. Clinical · 2017Pooled it
- BICC1 drives pancreatic cancer stemness and chemoresistance by facilitating tryptophan metabolism.Science advances · 2024Article
- Neuroimaging Genomics a Predictor of Major Depressive Disorder (MDD).Molecular neurobiology · 2024Review
- Bicaudal-C Post-transcriptional regulator of cell fates and functions.Frontiers in cell and developmental biology · 2022Review
- Protein Translation and Psychiatric Disorders.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2020Review
- Analysis of the effects of depression associated polymorphisms on the activity of the BICC1 promoter in amygdala neurones.The pharmacogenomics journal · 2016Article
- Single-Nucleotide Polymorphism of the FKBP5 Gene and Childhood Maltreatment as Predictors of Structural Changes in Brain Areas Involved in Emotional Processing in Depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- BICC1 expression is elevated in depressed subjects and contributes to depressive behavior in rodents.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genes and early-life adversity (ELA) interactively increase the risk of developing major depressive disorder (MDD). A recent genome-wide association study suggests that the minor T-allele of single-nucleotide polymorphisms in the bicaudal C homolog 1 gene (BICC1) has a protective role against MDD. The aims of the study were to investigate whether the minor T-allele of BICC1 is protective against hippocampal structural brain changes, whether it is associated with increased functional brain activity in the emotion regulation system, and how ELA would modify this association. Forty-four patients with MDD and 44 healthy controls were investigated using structural magnetic resonance imaging (MRI) and functional MRI with an emotion inhibition task. Analysis of a single-nucleotide polymorphism in the BICC1-1 (rs999845) gene was performed. Right hippocampal bodies of patients and controls without a history of ELA and who carry the protective T-allele of BICC1 were significantly larger compared with those participants homozygous for the major C-allele of BICC1. However, MDD patients with ELA, who carry the T-allele, had smaller hippocampal head volumes compared with MDD patients without ELA. FMRI showed that patients and controls carrying the protective T-allele of BICC1 activate the emotion regulation system significantly more compared with those participants homozygous for the major C-allele (p<0.05, family wise error corrected). These results are suggestive that the minor T-allele of BICC1 has a protective role against MDD and its known structural and functional brain changes. However, this protective effect seems to be lost in the case of co-occurrence of ELA.
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Registered trials
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