Evidence map›Paper›PMID 22910105›Full record

ArticleJournal of the American Academy of Dermatology2013

Variation in dermatologist beliefs about the safety and effectiveness of treatments for moderate to severe psoriasis.

Katrina Abuabara, Joy Wan, Andrea B Troxel, Daniel B Shin, Abby S Van Voorhees, Bruce F Bebo, Gerald G Krueger, Kristina Callis Duffin, Joel M Gelfand

Abstract read
In one paragraph

Article in Journal of the American Academy of Dermatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Katrina AbuabaraDepartment of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.
Joy Wan
Andrea B Troxel
Daniel B Shin
Abby S Van Voorhees
Bruce F Bebo
Gerald G Krueger
Kristina Callis Duffin
Joel M Gelfand

Funding

Penn Dermatology Research Training ProgramT32AR007465 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice, David Joel Margolis · 1986 to 2026
$9.0M
Mentored Scholars Program for Translational Comparative Effectiveness ResearchKM1CA156723 · NCI · UNIVERSITY OF UTAH · PI BYINGTON, CARRIE L. · 2010 to 2010
$2.5M
Comparative Effectiveness of Biologics for PsoriasisRC1AR058204 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI GELFAND, JOEL M · 2009 to 2010
$1.0M
Psoriasis and the Risk of DiabetesK24AR064310 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI GELFAND, JOEL M · 2013 to 2017
$870k
NCI NIH HHS 1KM1CA156723NCI NIH HHS KM1 CA156723NIAMS NIH HHS K24 AR064310NIAMS NIH HHS RC1 AR058204NIAMS NIH HHS RC1-AR058204NIAMS NIH HHS T32 AR007465NIAMS NIH HHS T32-AR07465
6 · The paper itself

Abstract

backgroundMultiple systemic treatments are available for moderate to severe psoriasis, but dermatologists' perceptions of these treatments are unknown. Physician perceptions can influence prescribing patterns and patient outcomes, and may help to explain variations in clinical practice.

objectiveWe sought to describe the variation in dermatologist's beliefs about the safety and effectiveness of psoriasis treatments and evaluate how these relate to dermatologist characteristics and treatment preferences.

methodsWe conducted a cross-sectional mail survey of a random sample of 500 National Psoriasis Foundation (NPF) members and 500 American Academy of Dermatology (AAD) members who treat psoriasis.

resultsOf 989 clinicians who could be contacted, 246 NPF members and 141 AAD members returned the survey (39% response rate). Respondents perceived infliximab, ustekinumab, cyclosporine, and adalimumab to have the highest likelihood of skin clearance in 3 months (67%-75%). Etanercept, adalimumab, ultraviolet B, and ustekinumab had the lowest perceived likelihood of side effects requiring treatment discontinuation (9%-11%). Up to 49% of respondents "didn't know" the effectiveness or likelihood of side effects; calculated coefficients of variation were higher for perceived likelihood of side effects than perceived effectiveness. There were few significant associations between safety and effectiveness perceptions and respondent characteristics, and treatment preferences were not consistently predictive of perceptions. LIMITATIONS: Only dermatologists with interest in treating psoriasis were surveyed and general perceptions were elicited via survey format. Perceptions may differ between survey respondents and nonrespondents.

conclusionsPsoriasis providers demonstrate wide variation in their perception of the effectiveness and especially safety of systemic treatments.

Indexed as

Practice Patterns, Physicians'AdalimumabAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedCross-Sectional StudiesCyclosporineDermatologyEtanerceptHumansImmunoglobulin GInfliximabPerceptionPhysiciansPsoriasisReceptors, Tumor Necrosis FactorUstekinumabAdalimumabAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedCyclosporineEtanerceptImmunoglobulin GInfliximabReceptors, Tumor Necrosis FactorUstekinumab

Identifiers

PMID22910105
PMCPMC3644426

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.