ReviewThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2013
Coupling mechanical forces to electrical signaling: molecular motors and the intracellular transport of ion channels.
Review in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Biomechanical microenvironment in peripheral nerve regeneration: from pathophysiological understanding to tissue engineering development.Theranostics · 2022Review
- Rapid and Reversible Development of Axonal Varicosities: A New Form of Neural Plasticity.Frontiers in molecular neuroscience · 2021Review
- Neurotheranostics as personalized medicines.Advanced drug delivery reviews · 2019Review
- Molecular Mechanoneurobiology: An Emerging Angle to Explore Neural Synaptic Functions.BioMed research international · 2015Review
- Physiological and pathological functions of mechanosensitive ion channels.Molecular neurobiology · 2014Review
- Ankyrin-G directly binds to kinesin-1 to transport voltage-gated Na+ channels into axons.Developmental cell · 2014Article
- Activation of conventional kinesin motors in clusters by Shaw voltage-gated K+ channels.Journal of cell science · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Proper localization of various ion channels is fundamental to neuronal functions, including postsynaptic potential plasticity, dendritic integration, action potential initiation and propagation, and neurotransmitter release. Microtubule-based forward transport mediated by kinesin motors plays a key role in placing ion channel proteins to correct subcellular compartments. PDZ- and coiled-coil-domain proteins function as adaptor proteins linking ionotropic glutamate and GABA receptors to various kinesin motors, respectively. Recent studies show that several voltage-gated ion channel/transporter proteins directly bind to kinesins during forward transport. Three major regulatory mechanisms underlying intracellular transport of ion channels are also revealed. These studies contribute to understanding how mechanical forces are coupled to electrical signaling and illuminating pathogenic mechanisms in neurodegenerative diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.