ArticleEuropean journal of clinical nutrition2012
Dietary salt intake is related to inflammation and albuminuria in primary hypertensive patients.
Article in European journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Meta-Analysis of the Effect of Dietary Sodium Restriction with or without Concomitant Renin-Angiotensin-Aldosterone System-Inhibiting Treatment on Albuminuria.Clinical journal of the American Society of Nephrology : CJASN · 2015Pooled it
- Development and validation of a predictive model for high-risk immune-related adverse events in gastric cancer patients treated with ICIs.Human vaccines & immunotherapeutics · 2026Article
- Determinants of High Salt Intake in Croatian Adults: Evidence from 24-Hour Urinary Sodium Excretion in the EH-UH 2 Study.Life (Basel, Switzerland) · 2026Article
- Relationship Between Salt Intake and Cardiovascular Disease.Journal of clinical hypertension (Greenwich, Conn.) · 2025Review
- Perinatal Exposure of Dams to a High Salt Diet Impaired Vascular Function and Elevated Biomarkers of Inflammation in the Offspring.Clinical Medicine Insights. Cardiology · 2025Article
- Association between urinary sodium-to-potassium ratio, elevated blood pressure phenotypes and microalbuminuria: Tehran Lipid and Glucose Study.Scientific reports · 2024Article
- Association of Common Foods with Inflammation and Mortality: Analysis from a Large Prospective Cohort Study.Journal of medicinal food · 2024Article
- Being overweight worsens the relationship between urinary sodium excretion and albuminuria: the Wakuya study.European journal of clinical nutrition · 2023Article
- Male kidney-specific BMAL1 knockout mice are protected from KAmerican journal of physiology. Renal physiology · 2023Article
- The role of dietary salt in metabolism and energy balance: Insights beyond cardiovascular disease.Diabetes, obesity & metabolism · 2023Review
- Article
- Combination of the effect of ginger and anti-inflammatory diet on children with obesity with nonalcoholic fatty liver disease: A randomized clinical trial.Food science & nutrition · 2023Article
- Review
- Longitudinal changes in blood pressure are preceded by changes in albuminuria and accelerated by increasing dietary sodium intake.Experimental gerontology · 2023Review
- Article
- Sodium-glucose co-transporter 2 inhibitor therapy: use in chronic kidney disease and adjunctive sodium restriction.Internal medicine journal · 2022Review
- Potential role of inflammation in relation to dietary sodium and β-carotene with non-alcoholic fatty liver disease: a mediation analysis.Nutrition & diabetes · 2022Article
- TNFα Triggers an Augmented Inflammatory Response in Brain Neurons from Dahl Salt-Sensitive Rats Compared with Normal Sprague Dawley Rats.Cellular and molecular neurobiology · 2022Article
- Sodium in relation with nonalcoholic fatty liver disease: A systematic review and meta-analysis of observational studies.Food science & nutrition · 2022Review
- High Estimated 24-Hour Urinary Sodium Excretion Is Related to Symptomatic Knee Osteoarthritis: A Nationwide Cross-Sectional Population-Based Study.The journal of nutrition, health & aging · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesIn this study, we hypothesized that dietary salt intake may be related with inflammation and albuminuria independently from blood pressure (BP) in non-diabetic hypertensive patients. SUBJECTS/
methodsA total of 224 patients with primary hypertension were included in the study. Serum C-reactive protein (CRP) levels, 24-h urine sodium and albumin excretion were measured in all patients. The subjects were divided into tertiles according to the level of 24-h urinary sodium excretion: low-salt-intake group (n = 76, mean urine sodium: 111.7 ± 29.1 mmol/24 h), medium-salt-intake group (n = 77, mean urine sodium: 166.1 ± 16.3 mmol/24 h) and high-salt-intake group (n = 71, mean urine sodium: 263.6 ± 68.3 mmol/24 h).
resultsSystolic and diastolic BP measurements of patients were similar in the three salt-intake groups. CRP and urinary albumin levels were significantly higher in high-salt-intake group compared with medium- and low-salt-intake groups (P = 0.0003 and P = 0.001, respectively). CRP was positively correlated with 24-h urinary sodium excretion (r = 0.28, P = 0.0008) and albuminuria, whereas albuminuria was positively correlated with 24-h urinary sodium excretion (r = 0.21, P = 0.0002). Multiple regression analysis revealed that urinary sodium excretion was an independent predictor of both CRP and albuminuria.
conclusionsThese findings suggest that high salt intake is associated with enhanced inflammation and target organ damage reflected by increased albuminuria in treated hypertensive patients independent of any BP effect.
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