ArticleNeuroscience2012
Expression of CaV3.2 T-type Ca²⁺ channels in a subpopulation of retinal type-3 cone bipolar cells.
Article in Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Calcium Channels in Retinal Function and Disease.Annual review of vision science · 2022Review
- Bayesian inference for biophysical neuron models enables stimulus optimization for retinal neuroprosthetics.eLife · 2020Article
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
- Electrophysiological fingerprints of OFF bipolar cells in rat retina.Scientific reports · 2016Article
- Light adaptation alters inner retinal inhibition to shape OFF retinal pathway signaling.Journal of neurophysiology · 2016Article
- CaV3.2 KO mice have altered retinal waves but normal direction selectivity.Visual neuroscience · 2015Article
- Kainate receptors mediate signaling in both transient and sustained OFF bipolar cell pathways in mouse retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Retinal bipolar cells and ganglion cells are known to possess voltage-gated T-type Ca(2+) channels. Previous electrophysiological recording studies suggested that there is differential expression of different T-type Ca(2+) channel α1 subunits among bipolar cells. The detailed expression patterns of the individual T-type Ca(2+) channel subunits in the retina, however, remain unknown. In this study, we examined the expression of the Ca(V)3.2 Ca(2+) channel α1 subunit in the mouse retina using immunohistochemical analysis and patch-clamp recordings together with a Ca(V)3.2 knock out (KO) mouse line. The specificity of a Ca(V)3.2 Ca(2+) channel antibody was first confirmed in recombinant T-type Ca(2+) channels expressed in human embryonic kidney (HEK) cells and in Ca(V)3.2 KO mice. Our immunohistochemical analysis indicates that the Ca(V)3.2 antibody labels a subgroup of type-3 cone bipolar cells (CBCs), the PKAβII-immunopositive type-3 CBCs. The labeling was observed throughout the cell including dendrites and axon terminals. Our patch-clamp recording results further demonstrate that Ca(V)3.2 Ca(2+) channels contribute to the T-type Ca(2+) current in a subpopulation of type-3 CBCs. The findings of this study provide new insights into understanding the functional roles of T-type Ca(2+) channels in retinal processing.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.