ArticleBMC evolutionary biology2012
Signatures of balancing selection are maintained at disease resistance loci following mating system evolution and a population bottleneck in the genus Capsella.
Article in BMC evolutionary biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- What has population genomics told us about the dynamics of selection and plant adaptation?Molecular biology and evolution · 2026Review
- Assessing the Evolutionary Potential of Endangered Populations Using Genomic Analyses of Selection in Ecologically Important Gene Regions.Molecular ecology · 2026Article
- Plant NLR diversity: the known unknowns of pan-NLRomes.The Plant cell · 2021Review
- Inference of coevolutionary dynamics and parameters from host and parasite polymorphism data of repeated experiments.PLoS computational biology · 2020Article
- RPW8/HR repeats control NLR activation in Arabidopsis thaliana.PLoS genetics · 2019Article
- Article
- Restriction associated DNA-genotyping at multiple spatial scales in Arabidopsis lyrata reveals signatures of pathogen-mediated selection.BMC genomics · 2018Article
- Evidence for Adaptive Introgression of Disease Resistance Genes Among Closely RelatedG3 (Bethesda, Md.) · 2017Article
- The effects of historical fragmentation on major histocompatibility complex class II β and microsatellite variation in the Aegean island reptile,Ecology and evolution · 2017Article
- Recombination Rate Heterogeneity within Arabidopsis Disease Resistance Genes.PLoS genetics · 2016Article
- R-gene variation across Arabidopsis lyrata subspecies: effects of population structure, selection and mating system.BMC evolutionary biology · 2016Article
- Loss and retention of resistance genes in five species of the Brassicaceae family.BMC plant biology · 2014Article
- Genomic variability as a driver of plant-pathogen coevolution?Current opinion in plant biology · 2014Review
- The maintenance of sex: Ronald Fisher meets the Red Queen.BMC evolutionary biology · 2013Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPopulation bottlenecks can lead to a loss of variation at disease resistance loci, which could have important consequences for the ability of populations to adapt to pathogen pressure. Alternatively, current or past balancing selection could maintain high diversity, creating a strong heterogeneity in the retention of polymorphism across the genome of bottlenecked populations. We sequenced part of the LRR region of 9 NBS-LRR disease resistance genes in the outcrossing Capsella grandiflora and the recently derived, bottlenecked selfing species Capsella rubella, and compared levels and patterns of nucleotide diversity and divergence with genome-wide reference loci.
resultsIn strong contrast with reference loci, average diversity at resistance loci was comparable between C. rubella and C. grandiflora, primarily due to two loci with highly elevated diversity indicative of past or present balancing selection. Average between-species differentiation was also reduced at the set of R-genes compared with reference loci, which is consistent with the maintenance of ancestral polymorphism.
conclusionsHistorical or ongoing balancing selection on plant disease resistance genes is a likely contributor to the retention of ancestral polymorphism in some regions of the bottlenecked Capella rubella genome.
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