ReviewProceedings of the National Academy of Sciences of the United States of America2012
Gene balance hypothesis: connecting issues of dosage sensitivity across biological disciplines.
Review in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 325 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
325 citing papers in PubMed, 615 citations in OpenAlex.
- Towards Improving Embryo Prioritization: Parallel Next Generation Sequencing of DNA and RNA from a Single Trophectoderm Biopsy.Scientific reports · 2019Trial
- Comparative genomics of nitrogen acquisition and assimilation gene-family copy-number architecture across chlorophytes.World journal of microbiology & biotechnology · 2026Article
- Genomic Expansion and Subgenome Expression Divergence of Sugar Transporters During Polyploid Evolution of Bamboos.Biology · 2026Article
- Dynamic and non-additive gene regulation shapes maize responses to simultaneous salt and cold stress.Functional & integrative genomics · 2026Article
- Glycogen deficiency impairs diurnal energy metabolism and cell division in Synechocystis.Plant physiology · 2026Article
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- Dosage-Associated Maternal Dominance and Tissue-Specific Paternal Expression in a Triploid Hybrid Between Grass Carp and Yellowcheek.Animals : an open access journal from MDPI · 2026Article
- Evolutionary trajectories of teleost olfactory signaling genes shaped by long-term redundancy after whole-genome duplication.iScience · 2026Article
- Programmable CRISPRtune dissects the transcriptional repressive activity of MeCP2.bioRxiv : the preprint server for biology · 2026Article
- Molecular evolution in light of regulatory-coding epistasis.EMBO reports · 2026Review
- Remodeling of the tuberization-controlling FLOWERING LOCUS T genes from non-tuberizing ancestor to potato.The Plant journal : for cell and molecular biology · 2026Article
- Distinct evolutionary trajectories of gene duplication modes in 40 diploid cotton genomes.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Large-scale genomic analysis reveals the origin and evolution of Glutathione S-transferases (GSTs) in plants.BMC genomics · 2026Article
- A sorghum-anchored pan-grass syntenic gene set in grasses.NAR genomics and bioinformatics · 2026Article
- Ancient Whole-Genome Duplication and Lineage-Specific Retention Shape the Diversification of bZIP Transcription Factors in Pooideae.Plants (Basel, Switzerland) · 2026Article
- Retinoic acid production via the ray-finned fish gene bco1l is essential for juvenile development.Genetics · 2026Article
- Time after time: a quarter century of progress in plant circadian biology.Npj biological timing and sleep · 2026Review
- The molecular evolution of vertebrate organs.Nature ecology & evolution · 2026Review
- Using reciprocally retained gene families to detect whole-genome multiplications in plants.Genome biology · 2026Article
265 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
We summarize, in this review, the evidence that genomic balance influences gene expression, quantitative traits, dosage compensation, aneuploid syndromes, population dynamics of copy number variants and differential evolutionary fate of genes after partial or whole-genome duplication. Gene balance effects are hypothesized to result from stoichiometric differences among members of macromolecular complexes, the interactome, and signaling pathways. The implications of gene balance are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.