ArticleProceedings of the National Academy of Sciences of the United States of America2012
Short-term plasticity constrains spatial organization of a hippocampal presynaptic terminal.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- A spatial model of autophosphorylation of CaMKII predicts that the lifetime of phospho-CaMKII after induction of synaptic plasticity is greatly prolonged by CaM-trapping.Frontiers in synaptic neuroscience · 2025Article
- A spatial model of autophosphorylation of CabioRxiv : the preprint server for biology · 2024Article
- Synapse-specific structural plasticity that protects and refines local circuits during LTP and LTD.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Vesicular release probability sets the strength of individual Schaffer collateral synapses.Nature communications · 2022Article
- Amyloid pathology disrupts gliotransmitter release in astrocytes.PLoS computational biology · 2022Article
- Multiscale modeling of presynaptic dynamics from molecular to mesoscale.PLoS computational biology · 2022Article
- Deep Learning-Assisted High-Throughput Analysis of Freeze-Fracture Replica Images Applied to Glutamate Receptors and Calcium Channels at Hippocampal Synapses.International journal of molecular sciences · 2020Article
- Multiplex imaging relates quantal glutamate release to presynaptic CaNature communications · 2019Article
- Spatially dispersed synapses yield sharply-tuned place cell responses through dendritic spike initiation.The Journal of physiology · 2018Article
- Synaptotagmin CaFrontiers in molecular neuroscience · 2018Review
- Degeneracy in the regulation of short-term plasticity and synaptic filtering by presynaptic mechanisms.The Journal of physiology · 2017Article
- RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Synaptic Multivesicular Release in the Cerebellar Cortex: Its Mechanism and Role in Neural Encoding and Processing.Cerebellum (London, England) · 2016Article
- Time-coded neurotransmitter release at excitatory and inhibitory synapses.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Inhibitory and excitatory axon terminals share a common nano-architecture of their Cav2.1 (P/Q-type) Ca(2+) channels.Frontiers in cellular neuroscience · 2015Article
- Nanodomain coupling explains Ca²⁺ independence of transmitter release time course at a fast central synapse.eLife · 2014Article
- Cav2.1 channels control multivesicular release by relying on their distance from exocytotic Ca2+ sensors at rat cerebellar granule cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Biophysical properties of presynaptic short-term plasticity in hippocampal neurons: insights from electrophysiology, imaging and mechanistic models.Frontiers in cellular neuroscience · 2014Review
- The number and organization of Ca2+ channels in the active zone shapes neurotransmitter release from Schaffer collateral synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
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5 authors.
Funding
Abstract
Although the CA3-CA1 synapse is critically important for learning and memory, experimental limitations have to date prevented direct determination of the structural features that determine the response plasticity. Specifically, the local calcium influx responsible for vesicular release and short-term synaptic facilitation strongly depends on the distance between the voltage-dependent calcium channels (VDCCs) and the presynaptic active zone. Estimates for this distance range over two orders of magnitude. Here, we use a biophysically detailed computational model of the presynaptic bouton and demonstrate that available experimental data provide sufficient constraints to uniquely reconstruct the presynaptic architecture. We predict that for a typical CA3-CA1 synapse, there are ~70 VDCCs located 300 nm from the active zone. This result is surprising, because structural studies on other synapses in the hippocampus report much tighter spatial coupling. We demonstrate that the unusual structure of this synapse reflects its functional role in short-term plasticity (STP).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.