ArticleAntimicrobial agents and chemotherapy2012
Toxicity mechanisms of amphotericin B and its neutralization by conjugation with arabinogalactan.
Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
- Amphotericin B promotes respiratory viral entry by enhancing late endosomal maturation and fusion via glucocerebrosidase-mediated ceramide remodeling.Nature communications · 2026Article
- Symmetric adenine methylation is an essential DNA modification in the early-diverging fungus Rhizopus microsporus.Nature communications · 2025Article
- New antifungal strategies and drug development against WHO critical priority fungal pathogens.Frontiers in cellular and infection microbiology · 2025Review
- Novel combinatorial approach: Harnessing HIV protease inhibitors to enhance amphotericin B's antifungal efficacy in cryptococcosis.PloS one · 2024Article
- Marine Meroterpenoids Isolated fromPharmaceuticals (Basel, Switzerland) · 2023Article
- Rapidly dissolving microneedle patch of amphotericin B for intracorneal fungal infections.Drug delivery and translational research · 2022Article
- Effect of Cold Atmospheric Plasma Jet Associated to Polyene Antifungals onMolecules (Basel, Switzerland) · 2021Article
- Polyhydroxyalkanoate/Antifungal Polyene Formulations with Monomeric Hydroxyalkanoic Acids for Improved Antifungal Efficiency.Antibiotics (Basel, Switzerland) · 2021Article
- Assessing the Bioactive Profile of Antifungal-Loaded Calcium Sulfate against Fungal Biofilms.Antimicrobial agents and chemotherapy · 2021Article
- Macrolides: From Toxins to Therapeutics.Toxins · 2021Review
- Evaluation of bisphenylthiazoles as a promising class for combating multidrug-resistant fungal infections.PloS one · 2021Article
- Branched amphotericin functional poly(Royal Society open science · 2021Article
- Targeted Propolis-Loaded Poly (Butyl) Cyanoacrylate Nanoparticles: An Alternative Drug Delivery Tool for the Treatment of Cryptococcal Meningitis.Frontiers in pharmacology · 2021Article
- Activity of Auranofin against Multiple Genotypes ofACS chemical neuroscience · 2020Article
- Preparation and In Vitro Evaluation of Alginate Microparticles Containing Amphotericin B for the Treatment ofInternational journal of biomaterials · 2020Article
- The Effects of Mentha × piperita Essential Oil onAntibiotics (Basel, Switzerland) · 2019Article
- Acute Kidney Injury and Urinary Biomarkers in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis.Open forum infectious diseases · 2017Article
- Cell Wall Changes in Amphotericin B-Resistant Strains from Candida tropicalis and Relationship with the Immune Responses Elicited by the Host.Antimicrobial agents and chemotherapy · 2016Article
- Solubilization Behavior of Polyene Antibiotics in Nanomicellar System: Insights from Molecular Dynamics Simulation of the Amphotericin B and Nystatin Interactions with Polysorbate 80.Molecules (Basel, Switzerland) · 2015Article
- Epidemiology and Risk Factors for Echinocandin Nonsusceptible Candida glabrata Bloodstream Infections: Data From a Large Multisite Population-Based Candidemia Surveillance Program, 2008-2014.Open forum infectious diseases · 2015Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amphotericin B (AMB) is an effective antifungal agent. However, its therapeutic use is hampered by its toxicity, mainly due to channel formation across kidney cell membranes and the disruption of postendocytic trafficking. We previously described a safe injectable AMB-arabinogalactan (AG) conjugate with neutralized toxicity. Here we studied the mechanism of the toxicity of free AMB and its neutralization by conjugation with AG. AMB treatment of a kidney cell line modulated the trafficking of three receptors (C-X-C chemokine receptor type 4 [CXCR4], M1 receptor, and human transferrin receptor [hTfnR]) due to an increase in endosomal pH. Similar data were also obtained in yeast but with an increase in vacuolar pH and the perturbation of Hxt2-green fluorescent protein (GFP) trafficking. The conjugation of AMB with AG neutralized all elements of the toxic activity of AMB in mammalian but not in fungal cells. Based on these results, we provide an explanation of how the conjugation of AMB with AG neutralizes its toxicity in mammalian cells and add to the knowledge of the mechanism of action of free AMB in both fungal and mammalian cells.
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