ArticleFrontiers in neural circuits2012
Activation of cortical 5-HT(3) receptor-expressing interneurons induces NO mediated vasodilatations and NPY mediated vasoconstrictions.
Article in Frontiers in neural circuits, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Nitric oxide is not responsible for initial sensory-induced neurovascular coupling response in the barrel cortex of lightly anesthetized mice.Neurophotonics · 2025Article
- Cerebral blood flow patterns induced by photoactivation based on laser speckle contrast imaging.Biomedical optics express · 2024Article
- Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice.Biological research · 2024Article
- Parvalbumin interneuron activity induces slow cerebrovascular fluctuations in awake mice.bioRxiv : the preprint server for biology · 2024Article
- Modulatory effects of noradrenergic and serotonergic signaling pathway on neurovascular coupling.Communications biology · 2024Article
- In mice and humans, brain microvascular contractility matures postnatally.Brain structure & function · 2023Article
- Contribution of animal models toward understanding resting state functional connectivity.NeuroImage · 2021Review
- Inverse neurovascular coupling contributes to positive feedback excitation of vasopressin neurons during a systemic homeostatic challenge.Cell reports · 2021Article
- Hypoxia-induced expression of neuronal nitric oxide synthase in astrocytes of human corpus callosum.Brain structure & function · 2021Article
- More than just summed neuronal activity: how multiple cell types shape the BOLD response.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Cerebral Microcirculation, Perivascular Unit, and Glymphatic System: Role of Aquaporin-4 as the Gatekeeper for Water Homeostasis.Frontiers in neurology · 2021Review
- Spatial and temporal patterns of nitric oxide diffusion and degradation drive emergent cerebrovascular dynamics.PLoS computational biology · 2020Article
- Optogenetic assessment of VIP, PV, SOM and NOS inhibitory neuron activity and cerebral blood flow regulation in mouse somato-sensory cortex.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Inhibitory Neuron Activity Contributions to Hemodynamic Responses and Metabolic Load Examined Using an Inhibitory Optogenetic Mouse Model.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Pathology of nNOS-Expressing GABAergic Neurons in Mouse Model of Alzheimer's Disease.Neuroscience · 2018Article
- Article
- Interneurons contribute to the hemodynamic/metabolic response to epileptiform discharges.Journal of neurophysiology · 2016Article
- NPY+-, but not PV+- GABAergic neurons mediated long-range inhibition from infra- to prelimbic cortex.Translational psychiatry · 2016Article
- Astrocyte-derived adenosine is central to the hypnogenic effect of glucose.Scientific reports · 2016Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GABAergic interneurons are local integrators of cortical activity that have been reported to be involved in the control of cerebral blood flow (CBF) through their ability to produce vasoactive molecules and their rich innervation of neighboring blood vessels. They form a highly diverse population among which the serotonin 5-hydroxytryptamine 3A receptor (5-HT(3A))-expressing interneurons share a common developmental origin, in addition to the responsiveness to serotonergic ascending pathway. We have recently shown that these neurons regroup two distinct subpopulations within the somatosensory cortex: Neuropeptide Y (NPY)-expressing interneurons, displaying morphological properties similar to those of neurogliaform cells and Vasoactive Intestinal Peptide (VIP)-expressing bipolar/bitufted interneurons. The aim of the present study was to determine the role of these neuronal populations in the control of vascular tone by monitoring blood vessels diameter changes, using infrared videomicroscopy in mouse neocortical slices. Bath applications of 1-(3-Chlorophenyl)biguanide hydrochloride (mCPBG), a 5-HT(3)R agonist, induced both constrictions (30%) and dilations (70%) of penetrating arterioles within supragranular layers. All vasoconstrictions were abolished in the presence of the NPY receptor antagonist (BIBP 3226), suggesting that they were elicited by NPY release. Vasodilations persisted in the presence of the VIP receptor antagonist VPAC1 (PG-97-269), whereas they were blocked in the presence of the neuronal Nitric Oxide (NO) Synthase (nNOS) inhibitor, L-NNA. Altogether, these results strongly suggest that activation of neocortical 5-HT(3A)-expressing interneurons by serotoninergic input could induces NO mediated vasodilatations and NPY mediated vasoconstrictions.
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