ArticleEuropean radiology2013
Changes in measured size of atherosclerotic plaque calcifications in dual-energy CT of ex vivo carotid endarterectomy specimens: effect of monochromatic keV image reconstructions.
Article in European radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Automatic spectral imaging protocol and iterative reconstruction for radiation dose reduction in typical hepatic hemangioma computed tomography with reduced iodine load: a preliminary study.The British journal of radiology · 2018Trial
- CT imaging features of carotid artery plaque vulnerability.Annals of translational medicine · 2020Review
- Variation of degree of stenosis quantification using different energy level with dual energy CT scanner.Neuroradiology · 2019Article
- Assessment of carotid plaque composition using fast-kV switching dual-energy CT with gemstone detector: comparison with extracorporeal and virtual histology-intravascular ultrasound.Neuroradiology · 2015Article
- Dual energy computed tomography quantification of carotid plaques calcification: comparison between monochromatic and polychromatic energies with pathology correlation.European radiology · 2015Article
- Nuclear medicine and the emergency department patient: an illustrative case-based approach.La Radiologia medica · 2015Review
- Multi-modal CT scanning in the evaluation of cerebrovascular disease patients.Cardiovascular diagnosis and therapy · 2014Review
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Authors and funding
8 authors.
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Abstract
objectiveThe aim of this study was to compare the size of the calcifications measured on the different keV images to a histological standard.
methodsFive ex vivo carotid endarterectomy (CEA) specimens were imaged with a dual-energy CT. CT images were reconstructed at different monochromatic spectral energies (40, 60, 77, 80, 100, 120, 140 keV). Cross-sectional area of the plaque calcifications present on each CT image was measured. The histological calcium areas on each corresponding CEA specimen were traced manually on digitised images of Toluidine Blue/Basic Fuchsin stained plastic sections. The CT images and corresponding histology sections were matched. The CT-derived calcium areas on each keV image were compared to the calcified area measurements by histology.
resultsA total of 107 histology sections were matched to corresponding CT images. The average calcified area per section by histology was 7.6 ± 7 mm(2) (range 0-26.4 mm(2)). There was no significant difference between the calcified areas measured by histology and those measured on CT-virtual monochromatic spectral (VMS) reconstructed images at 77 keV (P = 0.08), 80 keV (P = 0.20) and 100 keV (P = 0.14).
conclusionsCalcium area measured on the 80 keV image set was most comparable to the amount of calcium measured by histology.
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