ReviewNature reviews. Urology2012
Tissue engineering for the oncologic urinary bladder.
Review in Nature reviews. Urology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Pooled it
- Mechanisms and implications of epithelial cell plasticity in the bladder.Nature reviews. Urology · 2026Review
- Interlacing biology and engineering: An introduction to textiles and their application in tissue engineering.Materials today. Bio · 2025Review
- Recent advances and future directions in urinary system tissue engineering.Materials today. Bio · 2025Review
- Injectable, stretchable, toughened, bioadhesive composite hydrogel for bladder injury repair.RSC advances · 2023Article
- Evaluation of silk fibroin-based urinary conduits in a porcine model of urinary diversion.Frontiers in bioengineering and biotechnology · 2023Article
- Bladder Replacement Therapy.Bladder (San Francisco, Calif.) · 2023Review
- Research progress of biomaterials and innovative technologies in urinary tissue engineering.Frontiers in bioengineering and biotechnology · 2023Review
- A Novel Hybrid Membrane for Urinary Conduit Substitutes Based on Small Intestinal Submucosa Coupled with Two Synthetic Polymers.Journal of functional biomaterials · 2022Article
- Urinary Bladder Patch Made with Decellularized Vein Scaffold Seeded with Adipose-Derived Mesenchymal Stem Cells: Model in Rabbits.Biomedicines · 2022Article
- Tissue engineering in reconstructive urology-The current status and critical insights to set future directions-critical review.Frontiers in bioengineering and biotechnology · 2022Review
- Tissue Engineering and Its Potential to Reduce Prostate Cancer Treatment Sequelae-Narrative Review.Frontiers in surgery · 2021Review
- Stretchable collagen-coated polyurethane-urea hydrogel seeded with bladder smooth muscle cells for urethral defect repair in a rabbit model.Journal of materials science. Materials in medicine · 2019Article
- Towards clinical application of tissue engineering for erectile penile regeneration.Nature reviews. Urology · 2019Review
- Mesenchymal stromal cells modulate the molecular pattern of healing process in tissue-engineered urinary bladder: the microarray data.Stem cell research & therapy · 2019Article
- Concise Review: Tissue Engineering of Urinary Bladder; We Still Have a Long Way to Go?Stem cells translational medicine · 2017Review
- Biofabrication and biomaterials for urinary tract reconstruction.Research and reports in urology · 2017Review
- New Amniotic Membrane Based Biocomposite for Future Application in Reconstructive Urology.PloS one · 2016Article
- Controlled protein delivery in the generation of microvascular networks.Drug delivery and translational research · 2015Review
- Tissue-engineered urinary conduits.Current urology reports · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urinary diversion after radical cystectomy in patients with bladder cancer normally takes the form of an ileal conduit or neobladder. However, such diversions are associated with a number of complications including increased risk of infection. A plausible alternative is the construction of a neobladder (or bladder tissue) in vitro using autologous cells harvested from the patient. Biomaterials can be used as a scaffold for naturally occurring regenerative stem cells to latch onto to regrow the bladder smooth muscle and epithelium. Such engineered tissues show great promise in urologic tissue regeneration, but are faced with a number of challenges. For example, the differentiation mesenchymal stem cells from various sources can be difficult and the smooth muscle cells formed do not precisely mimic the natural cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.